ArticleProceedings of the National Academy of Sciences of the United States of America2023
Gating of homeostatic regulation of intrinsic excitability produces cryptic long-term storage of prior perturbations.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- First-in-human study of epidural spinal cord stimulation in individuals with spinal muscular atrophy.Nature medicine · 2025Trial
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- Sensitivity of a model oscillator to shifts in the voltage-dependence of one or more ionic currents.Journal of neurophysiology · 2026Article
- When can neuronal activity-dependent homeostatic plasticity maintain circuit-level properties?Journal of computational neuroscience · 2026Article
- Persistent adaptation through dual-timescale regulation of ion channel properties.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
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- Persistent Adaptation through Dual-Timescale Regulation of Ion Channel Properties.bioRxiv : the preprint server for biology · 2025Article
- Degeneracy Explains Diversity in Interneuronal Regulation of Pattern Separation in Heterogeneous Dentate Gyrus Networks.Function (Oxford, England) · 2025Article
- Homeostatic regulation of a motor circuit through temperature sensing rather than activity sensing.Current biology : CB · 2025Article
- Hibernation reduces GABA signaling in the brainstem to enhance motor activity of breathing at cool temperatures.BMC biology · 2024Article
- Hibernation reduces GABA signaling in the brainstem to enhance motor activity of breathing at cool temperatures.bioRxiv : the preprint server for biology · 2024Article
- The Brain's Best Kept Secret Is Its Degenerate Structure.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- A possible path to persistent re-entry waves at the outlet of the left pulmonary vein.NPJ systems biology and applications · 2024Article
- Linking activity dyshomeostasis and sleep disturbances in Alzheimer disease.Nature reviews. Neuroscience · 2024Review
- Do calcium channel blockers applied to cardiomyocytes cause increased channel expression resulting in reduced efficacy?NPJ systems biology and applications · 2024Article
- A biophysical perspective on the resilience of neuronal excitability across timescales.Nature reviews. Neuroscience · 2023Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Neurons and neuronal circuits must maintain their function throughout the life of the organism despite changing environments. Previous theoretical and experimental work suggests that neurons monitor their activity using intracellular calcium concentrations to regulate their intrinsic excitability. Models with multiple sensors can distinguish among different patterns of activity, but previous work using models with multiple sensors produced instabilities that lead the models' conductances to oscillate and then to grow without bound and diverge. We now introduce a nonlinear degradation term that explicitly prevents the maximal conductances to grow beyond a bound. We combine the sensors' signals into a master feedback signal that can be used to modulate the timescale of conductance evolution. Effectively, this means that the negative feedback can be gated on and off according to how far the neuron is from its target. The modified model recovers from multiple perturbations. Interestingly, depolarizing the models to the same membrane potential with current injection or with simulated high extracellular
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.