Evidence map›Paper›PMID 37339811›Full record

Trial reportAddiction (Abingdon, England)2023

Motivational interviewing and problem-solving therapy intervention for patients on antiretroviral therapy for HIV in Tshwane, South Africa: A randomized controlled trial to assess the impact on alcohol consumption.

Charles D H Parry, Bronwyn Myers, Mukhethwa Londani, Paul A Shuper, Charl Janse van Rensburg, Samuel O M Manda, Sebenzile Nkosi, Connie T Kekwaletswe, Judith A Hahn, Jürgen Rehm and 2 more

Open access · hybridAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Addiction (Abingdon, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 6 countries.

Charles D H ParryAlcohol, Tobacco and Other Drug Research Unit, South African Medical Research Council, Cape Town, South Africa.ORCID 0000-0001-9787-2785
Bronwyn MyersAlcohol, Tobacco and Other Drug Research Unit, South African Medical Research Council, Cape Town, South Africa.ORCID 0000-0003-0235-6716
Mukhethwa LondaniAlcohol, Tobacco and Other Drug Research Unit, South African Medical Research Council, Pretoria, South Africa.
Paul A ShuperAlcohol, Tobacco and Other Drug Research Unit, South African Medical Research Council, Cape Town, South Africa.
Charl Janse van RensburgBiostatistics Unit, South African Medical Research Council, Pretoria, South Africa and Department of Statistics, University of Pretoria, Pretoria, South Africa.
Samuel O M MandaBiostatistics Unit, South African Medical Research Council, Pretoria, South Africa and Department of Statistics, University of Pretoria, Pretoria, South Africa.
Sebenzile NkosiAlcohol, Tobacco and Other Drug Research Unit, South African Medical Research Council, Pretoria, South Africa.
Connie T KekwaletsweAlcohol, Tobacco and Other Drug Research Unit, South African Medical Research Council, Pretoria, South Africa.
Judith A HahnDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0002-2697-8264
Jürgen RehmInstitute for Mental Health Policy Research and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.ORCID 0000-0001-5665-0385
Katherine SorsdahlAlan J Flisher Centre for Public Mental Health, Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Neo K MorojeleAlcohol, Tobacco and Other Drug Research Unit, South African Medical Research Council, Pretoria, South Africa.
South African Medical Research Council · ZACentre for Addiction and Mental Health · CAUniversity of California, San Francisco · USUniversity of Cape Town · ZA

Funding

Training in Research Program on Alcohol Use by Persons with our at Risk for HIVK24AA022586 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HAHN, JUDITH ALISSA · 2013 to 2023
$1.8M
Sustainable Academic Capacity Building of Excellence through Research and Training Program (SACERT) Learning CollaborativeD43TW012029 · FIC · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MILBURN, NORWEETA GERMAINE, WYATT, GAIL E. · 2021 to 2025
$1.5M
FIC NIH HHS D43 TW012029NIAAA NIH HHS K24 AA022586
6 · The paper itself

Abstract

BACKGROUND AND

aimsReduction of alcohol consumption is important for people undergoing treatment for HIV. We tested the efficacy of a brief intervention for reducing the average volume of alcohol consumed among patients on HIV antiretroviral therapy (ART). DESIGN, SETTING AND

participantsThis study used a two-arm multi-centre randomized controlled trial with follow-up to 6 months. Recruitment occurred between May 2016 and October 2017 at six ART clinics at public hospitals in Tshwane, South Africa. Participants were people living with HIV, mean age 40.8 years [standard deviation (SD) = 9.07], 57.5% female, and on average 6.9 years (SD = 3.62) on ART. At baseline (BL), the mean number of drinks consumed over the past 30 days was 25.2 (SD = 38.3). Of 756 eligible patients, 623 were enrolled.

interventionParticipants were randomly assigned to a motivational interviewing (MI)/problem-solving therapy (PST) intervention arm (four modules of MI and PST delivered over two sessions by interventionists) or a treatment as usual (TAU) comparison arm. People assessing outcomes were masked to group assignment. MEASUREMENTS: The primary outcome was the number of standard drinks (15 ml pure alcohol) consumed during the past 30 days assessed at 6-month follow-up (6MFU).

findingsOf the 305 participants randomized to MI/PST, 225 (74%) completed the intervention (all modules). At 6MFU, retention was 88% for the control and 83% for the intervention arm. In support of the hypothesis, an intention-to-treat-analysis for the primary outcome at 6MFU was -0.410 (95% confidence interval = -0.670 to -0.149) units lower on log scale in the intervention group than in the control group (P = 0.002), a 34% relative reduction in the number of drinks. Sensitivity analyses were undertaken for patients who had alcohol use disorders identification test (AUDIT) scores ≥ 8 at BL (n = 299). Findings were similar to those of the whole sample.

conclusionsIn South Africa, a motivational interviewing/problem-solving therapy intervention significantly reduced drinking levels in HIV-infected patients on antiretroviral therapy at 6-month follow-up.

Indexed as

AlcoholismHIV InfectionsMotivational InterviewingAdultAlcohol DrinkingFemaleHumansMaleSouth AfricaAlcoholbrief interventionPLWHIVproblem-solving therapySouth Africa

Identifiers

PMID37339811
PMCPMC10592292
OpenAlexW4381325678

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.