Evidence map›Paper›PMID 37339963›Full record

ArticleNature communications2023

Gut microbiota Turicibacter strains differentially modify bile acids and host lipids.

Jonathan B Lynch, Erika L Gonzalez, Kayli Choy, Kym F Faull, Talia Jewell, Abelardo Arellano, Jennifer Liang, Kristie B Yu, Jorge Paramo, Elaine Y Hsiao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 218 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
218citing papers in PubMed, 1 pooled it
43.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

218 citing papers in PubMed, 1 synthesis or guideline pooled it, 276 citations in OpenAlex.

  1. Pooled it
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  3. Testosterone administration partially modulates gut microbiota responses to severe energy deficit.American journal of physiology. Endocrinology and metabolism · 2026
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158 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jonathan B LynchDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA. jlynch48@jhmi.edu.ORCID 0000-0001-5221-7090
Erika L GonzalezDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Kayli ChoyDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Kym F FaullDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Talia JewellIsolation Bio, San Carlos, CA, 94070, USA.
Abelardo ArellanoIsolation Bio, San Carlos, CA, 94070, USA.
Jennifer LiangIsolation Bio, San Carlos, CA, 94070, USA.
Kristie B YuDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Jorge ParamoDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Elaine Y HsiaoDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.ORCID 0000-0002-1633-588X
University of California, Los Angeles · USJohns Hopkins University · USUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacteria from the Turicibacter genus are prominent members of the mammalian gut microbiota and correlate with alterations in dietary fat and body weight, but the specific connections between these symbionts and host physiology are poorly understood. To address this knowledge gap, we characterize a diverse set of mouse- and human-derived Turicibacter isolates, and find they group into clades that differ in their transformations of specific bile acids. We identify Turicibacter bile salt hydrolases that confer strain-specific differences in bile deconjugation. Using male and female gnotobiotic mice, we find colonization with individual Turicibacter strains leads to changes in host bile acid profiles, generally aligning with those produced in vitro. Further, colonizing mice with another bacterium exogenously expressing bile-modifying genes from Turicibacter strains decreases serum cholesterol, triglycerides, and adipose tissue mass. This identifies genes that enable Turicibacter strains to modify host bile acids and lipid metabolism, and positions Turicibacter bacteria as modulators of host fat biology.

Indexed as

Gastrointestinal MicrobiomeTenericutesAnimalsBacteriaBileBile Acids and SaltsDietary FatsFemaleHumansMaleMammalsMiceBile Acids and SaltsDietary Fats

Identifiers

PMID37339963
PMCPMC10281990
OpenAlexW4381436569

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.