Evidence map›Paper›PMID 37343180›Full record

ArticleJournal of medicinal chemistry2023

Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues.

Laura A T Cleghorn, Richard J Wall, Sébastien Albrecht, Stuart A MacGowan, Suzanne Norval, Manu De Rycker, Andrew Woodland, Daniel Spinks, Stephen Thompson, Stephen Patterson and 12 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 2 institutions in 1 country.

Laura A T CleghornDrug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
Richard J WallWellcome Centre for Anti-infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
Sébastien AlbrechtDrug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
Stuart A MacGowanDivision of Computational Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.ORCID 0000-0003-4233-5071
Suzanne NorvalDrug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
Manu De RyckerDrug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.ORCID 0000-0002-3171-3519
Andrew WoodlandDrug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
Daniel SpinksDrug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
Stephen ThompsonDrug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
Stephen PattersonWellcome Centre for Anti-infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
Victoriano Corpas LopezWellcome Centre for Anti-infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
Gourav DeyWellcome Centre for Anti-infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
Iain T CollieDrug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
Irene HallyburtonDrug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
Robert KimeDrug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
Frederick R C SimeonsDrug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
Laste StojanovskiDrug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
Julie A FrearsonDrug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
Paul G WyattDrug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
Kevin D ReadDrug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.ORCID 0000-0002-8536-0130
Ian H GilbertDrug Discovery Unit, Wellcome Centre for Anti-infectives Research, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.ORCID 0000-0002-5238-1314
Susan WyllieWellcome Centre for Anti-infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.ORCID 0000-0001-8810-5605
Wellcome Centre for Anti-Infectives Research · GBUniversity of Dundee · GB

Funding

Wellcome Trust 105021Wellcome Trust 203134/Z/16/ZWellcome Trust 218448/Z/19/ZWellcome Trust WT077705Wellcome Trust WT083481
6 · The paper itself

Abstract

While treatment options for human African trypanosomiasis (HAT) have improved significantly, there is still a need for new drugs with eradication now a realistic possibility. Here, we report the development of 2,4-diaminothiazoles that demonstrate significant potency against

Indexed as

Cytostatic AgentsTrypanocidal AgentsTrypanosoma brucei bruceiTrypanosomiasis, AfricanAnimalsBlood-Brain BarrierHumansCytostatic AgentsTrypanocidal Agents

Identifiers

PMID37343180
PMCPMC10350920
OpenAlexW4381599065

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.