Evidence map›Paper›PMID 37346145›Full record

ArticleAging brain2023

Monitoring clusterin and fibrillar structures in aging and dementia.

Dário Trindade, Maria Cachide, Tânia Soares Martins, Sandra Guedes, Ilka M Rosa, Odete A B da Cruz E Silva, Ana Gabriela Henriques

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging brain, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Dário TrindadeNeuroscience and Signaling Group, Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, Portugal.
Maria CachideNeuroscience and Signaling Group, Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, Portugal.
Tânia Soares MartinsNeuroscience and Signaling Group, Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, Portugal.
Sandra GuedesNeuroscience and Signaling Group, Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, Portugal.
Ilka M RosaNeuroscience and Signaling Group, Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, Portugal.
Odete A B da Cruz E SilvaNeuroscience and Signaling Group, Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, Portugal.
Ana Gabriela HenriquesNeuroscience and Signaling Group, Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, Portugal.
University of Aveiro · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Clusterin is involved in a variety of physiological processes, including proteostasis. Several clusterin polymorphisms were associated with an increased risk of developing Alzheimer's disease, the world-leading cause of dementia. Herein, the effect of a clusterin polymorphism, aging and dementia in the levels of clusterin in human plasma were analysed in a primary care-based cohort, and the association of this chaperone with fibrillar structures discussed. Methods: 64 individuals with dementia (CDR≥1) and 64 age- and sex-matched Controls from a Portuguese cohort were genotyped for CLU rs1136000 polymorphism, and the plasma levels of clusterin and fibrils were assessed. Results: An increased prevalence of the CC genotype was observed for the dementia group, although no significant robustness was achieved. CLU rs11136000 SNP did not significantly change plasma clusterin levels in demented individuals. Instead, clusterin levels decreased with aging and even more in individuals with dementia. Importantly, plasma clusterin levels correlated with the presence of fibrillar structures in Control individuals, but not in those with dementia. Conclusion: This study reveals a significant decrease in plasma clusterin in demented individuals with aging, which related to altered clusterin-fibrils dynamics. Potentially, plasma clusterin and its association with fibrillar structures can be used to monitor dementia progression along aging.

Indexed as

AgingAlzheimer’s diseaseClusterinDementiaFibrils

Identifiers

PMID37346145
PMCPMC10279921
OpenAlexW4379793012

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.