Evidence map›Paper›PMID 37350564›Full record

ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2023

Developmental Expression of the Cell Cycle Regulator p16

Cristina Martinez-Fernandez de la Camara, Tina Storm, Ahmed Salman, Thomas Burgoyne, Martin Qvist Rasmussen, Harry O Orlans, Angela J Russell, Stephen G Davies, Alun R Barnard, Robert E MacLaren

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 74% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Cristina Martinez-Fernandez de la CamaraNuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-6612-6162
Tina StormNuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-6550-4072
Ahmed SalmanNuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-4300-2033
Thomas BurgoyneInstitute of Ophthalmology, University College London, London, United Kingdom.ORCID 0000-0002-8428-720X
Martin Qvist RasmussenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Harry O OrlansNuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Angela J RussellChemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom.
Stephen G DaviesChemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom.
Alun R BarnardNuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Robert E MacLarenNuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
University of Oxford · GBJohn Radcliffe Hospital · GBAarhus University · DKRoyal Brompton & Harefield NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retinal astrocytes are vital for neuronal homeostasis in the retina. Together with Müller glia, they provide retinal cells with neurotrophic factors, antioxidative support, and defense mechanisms such as the formation of the blood-retinal barrier. Substantial heterogeneity of astrocyte morphology and function represents a challenge for identification of distinct subtypes which may be potential targets for therapeutic purposes. Hence, identification of novel markers of astrocyte subpopulations is highly relevant to better understand the molecular mechanisms involved in retinal development, homeostasis, and pathology. In this study, we observed that the cell cycle regulator, p16

Indexed as

AstrocytesCyclin-Dependent Kinase Inhibitor p16AnimalsCell CycleGlial Fibrillary Acidic ProteinMiceNeurogliaRetinaCyclin-Dependent Kinase Inhibitor p16Glial Fibrillary Acidic ProteinastrocytesMüller glianerve fiber layeroptic nervep16INK4a

Identifiers

PMID37350564
PMCPMC10315990
OpenAlexW4381716336

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.