Evidence map›Paper›PMID 37352010›Full record

ArticleEnvironmental health perspectives2023

A Case for Accelerating Standards to Achieve the FAIR Principles of Environmental Health Research Experimental Data.

Rance Nault, Matthew C Cave, Gabriele Ludewig, Hunter N B Moseley, Kelly G Pennell, Tim Zacharewski

Abstract read
In one paragraph

Article in Environmental health perspectives, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Application of a metabolic network-based graph neural network for the identification of toxicant-induced perturbations.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rance NaultBiochemistry & Molecular Biology Department, Institute for Integrative Toxicology, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0002-6822-4962
Matthew C CaveDivision of Gastroenterology, Hepatology, and Nutrition, University of Louisville, Louisville, Kentucky, USA.
Gabriele LudewigDepartment of Occupational and Environmental Health, University of Iowa, Iowa City, Iowa, USA.
Hunter N B MoseleyMolecular and Cellular Biochemistry Department, University of Kentucky, Lexington, Kentucky, USA.
Kelly G PennellDepartment of Civil Engineering, University of Kentucky, Lexington, Kentucky, USA.
Tim ZacharewskiBiochemistry & Molecular Biology Department, Institute for Integrative Toxicology, Michigan State University, East Lansing, Michigan, USA.

Funding

VOLATILE ORGANIC CONTAMINANTS--QUANTIFYING THEIR MOVEMENT IN THE UNSATURATED ZONEP42ES004911 · NIEHS · MICHIGAN STATE UNIVERSITY · PI Timothy R. Zacharewski · 1989 to 2026
$64.9M
Training CoreP42ES013661 · NIEHS · UNIVERSITY OF IOWA · PI KAI WANG · 2006 to 2026
$60.3M
Vascular Mechanisms of PCB-Induced Brain MetastasesP42ES007380 · NIEHS · UNIVERSITY OF KENTUCKY · PI MORRIS, ANDREW J · 1997 to 2024
$47.8M
Superfund Training CoreP42ES023716 · NIEHS · UNIVERSITY OF LOUISVILLE · PI SRIVASTAVA, SANJAY · 2017 to 2025
$18.1M
University of Louisville Center for Integrative Environmental Health SciencesP30ES030283 · NIEHS · UNIVERSITY OF LOUISVILLE · PI Amanda Jo LeBlanc · 2020 to 2026
$10.0M
AhR-dependent Pkm2 regulation in NAFLD progressionR01ES029541 · NIEHS · MICHIGAN STATE UNIVERSITY · PI ZACHAREWSKI, TIMOTHY R. · 2019 to 2023
$1.9M
NIEHS NIH HHS P30 ES030283NIEHS NIH HHS P42 ES004911NIEHS NIH HHS P42 ES007380NIEHS NIH HHS P42 ES013661NIEHS NIH HHS P42 ES023716NIEHS NIH HHS R01 ES029541
6 · The paper itself

Abstract

backgroundFunding agencies, publishers, and other stakeholders are pushing environmental health science investigators to improve data sharing; to promote the findable, accessible, interoperable, and reusable (FAIR) principles; and to increase the rigor and reproducibility of the data collected. Accomplishing these goals will require significant cultural shifts surrounding data management and strategies to develop robust and reliable resources that bridge the technical challenges and gaps in expertise.

objectiveIn this commentary, we examine the current state of managing data and metadata-referred to collectively as (meta)data-in the experimental environmental health sciences. We introduce new tools and resources based on

methodsWe discuss previous and ongoing efforts to improve (meta)data collection and curation. These include global efforts by the Functional Genomics Data Society to develop metadata collection tools such as the Investigation, Study, Assay (ISA) framework, and the Center for Expanded Data Annotation and Retrieval. We also conduct a case study of DISCUSSION: The environmental health science community has played a key role in efforts to achieve the goals of the FAIR guiding principles and is well positioned to advance them further. We present a proposed framework to further promote these objectives and minimize the obstacles between data producers and data scientists to maximize the return on research investments. https://doi.org/10.1289/EHP11484.

Indexed as

Environmental HealthGenomicsInformation DisseminationMetadataReproducibility of Results

Identifiers

PMID37352010
PMCPMC10289218

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.