SynthesisDiabetes care2023
Type 2 Diabetes Polygenic Score Predicts the Risk of Glucocorticoid-Induced Hyperglycemia in Patients Without Diabetes.
Synthesis in Diabetes care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Refining the Genetic Contribution to Type 2 Diabetes Subtypes.Diabetes, obesity & metabolism · 2026Article
- Steroid-Induced Hyperglycaemia in a Patient With Possible Body Dissatisfaction: A Case Report.Cureus · 2025Article
- Opportunistic screening of type 2 diabetes with deep metric learning using electronic health records.Scientific reports · 2025Article
- Genetic risk and polygenic risk score assessment of prediabetes and progression to type 2 diabetes.Diabetes, obesity & metabolism · 2025Article
- Article
- XPRS: a tool for interpretable and explainable polygenic risk score.Bioinformatics (Oxford, England) · 2025Article
- Influence and role of polygenic risk score in the development of 32 complex diseases.Journal of global health · 2025Article
- Integrating Polygenic Risk Scores (PRS) for Personalized Diabetes Care: Advancing Clinical Practice with Tailored Pharmacological Approaches.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025Review
- Single-cell Transcriptomics, Web-based Systems Pharmacology and Integrated Transcriptomics Network Analysis Identified Diagnostic Targets and Drug Candidates for Type 2 Diabetes.Endocrine, metabolic & immune disorders drug targets · 2025Article
- Validation of GenProb-T1D and its clinical utility for differentiating types of diabetes in a biobank from a US healthcare system.Journal of diabetes investigation · 2025Article
- Is It Time for a New Algorithm for the Pharmacotherapy of Steroid-Induced Diabetes?Journal of clinical medicine · 2024Review
- Glucocorticoid-Induced Hyperglycemia: A Neglected Problem.Endocrinology and metabolism (Seoul, Korea) · 2024Review
- Effectiveness of Corticosteroid Therapy in Enhancing Early Postoperative Recovery in Lumbar Spinal Stenosis Patients: A Retrospective Study.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo assess whether increased genetic risk of type 2 diabetes (T2D) is associated with the development of hyperglycemia after glucocorticoid treatment. RESEARCH DESIGN AND
methodsWe performed a retrospective analysis of individuals with no diagnosis of diabetes who received a glucocorticoid dose of ≥10 mg prednisone. We analyzed the association between hyperglycemia and a T2D global extended polygenic score, which was constructed through a meta-analysis of two published genome-wide association studies.
resultsOf 546 individuals who received glucocorticoids, 210 developed hyperglycemia and 336 did not. T2D polygenic score was significantly associated with glucocorticoid-induced hyperglycemia (odds ratio 1.4 per SD of polygenic score; P = 0.038).
conclusionsIndividuals with increased genetic risk of T2D have a higher risk of glucocorticoid-induced hyperglycemia. This finding offers a mechanism for risk stratification as part of a precision approach to medical treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.