Evidence map›Paper›PMID 37360692›Full record

ReviewiScience2023

What the BTBR/J mouse has taught us about diabetes and diabetic complications.

Mark P Keller, Kelly L Hudkins, Anath Shalev, Sushant Bhatnagar, Melkam A Kebede, Matthew J Merrins, Dawn Belt Davis, Charles E Alpers, Michelle E Kimple, Alan D Attie

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. The prostaglandin EAmerican journal of physiology. Endocrinology and metabolism · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Mark P KellerDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Kelly L HudkinsDepartment of Pathology, University of Washington Medical Center, Seattle, WA 98195, USA.
Anath ShalevDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, Birmingham, AL 35294, UK.
Sushant BhatnagarDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, Birmingham, AL 35294, UK.
Melkam A KebedeSchool of Medical Sciences, Faculty of Medicine and Health, Charles Perkins Centre, University of Sydney, Camperdown, Sydney, NSW 2006, Australia.
Matthew J MerrinsDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Dawn Belt DavisDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Charles E AlpersDepartment of Pathology, University of Washington Medical Center, Seattle, WA 98195, USA.
Michelle E KimpleDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Alan D AttieDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
University of Wisconsin–Madison · USUniversity of Alabama at Birmingham · USUniversity of Washington Medical Center · USThe University of Sydney · AU

Funding

The role of Tomosyn-2 in insulin secretion and glucose toleranceR01DK120684 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Sushant Bhatnagar · 2019 to 2026
$2.6M
The role of GLP-1 and CCK in the pancreatic islet to promote beta-cell survivalR01DK110324 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI DAVIS, DAWN B · 2016 to 2020
$2.0M
Molecular Mechanisms of Dysfunctional Prostaglandin Signaling in the Beta-CellR01DK102598 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI KIMPLE, MICHELLE E · 2014 to 2018
$1.7M
THE ROLE OF TOMOSYN-2 IN INSULIN SECRETIONR00DK095975 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BHATNAGAR, SUSHANT · 2016 to 2018
$735k
The role of tomosyn-2 in insulin secretionK99DK095975 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI BHATNAGAR, SUSHANT · 2014 to 2015
$177k
Transcriptional Regulation of Pancreatic Beta Cell MassI01BX001880 · VA · WM S. MIDDLETON MEMORIAL VETERANS HOSP · PI DAVIS, DAWN B · 2013 to 2016
–
G protein mediated mechanisms of beta-cell compensation and failure in type 2 diabetesI01BX005804 · VA · WM S. MIDDLETON MEMORIAL VETERANS HOSP · PI Michelle E Kimple · 2023 to 2026
–
Functional studies of the novel diabetes gene TCF19I01BX004715 · VA · WM S. MIDDLETON MEMORIAL VETERANS HOSP · PI DAVIS, DAWN B · 2019 to 2023
–
G Protein Mediated Mechanisms of Beta Cell Death Dysfunction and Decompensation in DiabetesI01BX003700 · VA · WM S. MIDDLETON MEMORIAL VETERANS HOSP · PI KIMPLE, MICHELLE E · 2018 to 2021
–
BLRD VA I01 BX001880BLRD VA I01 BX003700BLRD VA I01 BX004715BLRD VA I01 BX005804NIDDK NIH HHS K99 DK095975NIDDK NIH HHS R00 DK095975NIDDK NIH HHS R01 DK102598NIDDK NIH HHS R01 DK110324NIDDK NIH HHS R01 DK120684
6 · The paper itself

Abstract

Human and mouse genetics have delivered numerous diabetogenic loci, but it is mainly through the use of animal models that the pathophysiological basis for their contribution to diabetes has been investigated. More than 20 years ago, we serendipidously identified a mouse strain that could serve as a model of obesity-prone type 2 diabetes, the BTBR (Black and Tan Brachyury) mouse (BTBR T+ Itpr3tf/J, 2018) carrying the

Indexed as

Animal physiologyHuman metabolismModel organism

Identifiers

PMID37360692
PMCPMC10285641
OpenAlexW4379742506

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.