Evidence map›Paper›PMID 37364098›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Synthetic molecular motor activates drug delivery from polymersomes.

Ainoa Guinart, Maria Korpidou, Daniel Doellerer, Gianni Pacella, Marc C A Stuart, Ionel Adrian Dinu, Giuseppe Portale, Cornelia Palivan, Ben L Feringa

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Coupling Rotary Motion to Helicene Inversion within a Molecular Motor.Angewandte Chemie (International ed. in English) · 2025
    Article
  11. Article
  12. Photoreceptor-Like Signal Transduction Between Polymer-Based Protocells.Advanced materials (Deerfield Beach, Fla.) · 2025
    Article
  13. Article
  14. Molecular Motors' Magic Methyl and Its Pivotal Influence on Rotation.Journal of the American Chemical Society · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Molecular Machines For The Control Of Transmembrane Transport.Journal of the American Chemical Society · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ainoa GuinartFaculty of Science and Engineering, Stratingh Institute for Chemistry, University of Groningen, 9747 AG Groningen, The Netherlands.ORCID 0000-0003-0355-7296
Maria KorpidouDepartment of Chemistry, University of Basel, BPR 1096, 4058 Basel, Switzerland.ORCID 0000-0002-1543-6005
Daniel DoellererFaculty of Science and Engineering, Stratingh Institute for Chemistry, University of Groningen, 9747 AG Groningen, The Netherlands.
Gianni PacellaFaculty of Science and Engineering, Zernike Institute for Advanced Materials, University of Groningen, 9747 AG Groningen, The Netherlands.ORCID 0000-0001-8462-4977
Marc C A StuartFaculty of Science and Engineering, Stratingh Institute for Chemistry, University of Groningen, 9747 AG Groningen, The Netherlands.ORCID 0000-0003-0667-6338
Ionel Adrian DinuDepartment of Chemistry, University of Basel, BPR 1096, 4058 Basel, Switzerland.ORCID 0000-0002-8208-939X
Giuseppe PortaleFaculty of Science and Engineering, Zernike Institute for Advanced Materials, University of Groningen, 9747 AG Groningen, The Netherlands.
Cornelia PalivanDepartment of Chemistry, University of Basel, BPR 1096, 4058 Basel, Switzerland.ORCID 0000-0001-7777-5355
Ben L FeringaFaculty of Science and Engineering, Stratingh Institute for Chemistry, University of Groningen, 9747 AG Groningen, The Netherlands.ORCID 0000-0003-0588-8435

Funding

European Research Council 694345Marie Curie 859416
6 · The paper itself

Abstract

The design of stimuli-responsive systems in nanomedicine arises from the challenges associated with the unsolved needs of current molecular drug delivery. Here, we present a delivery system with high spatiotemporal control and tunable release profiles. The design is based on the combination of an hydrophobic synthetic molecular rotary motor and a PDMS-

Indexed as

Drug Delivery SystemsPolymersCell LineDimethylpolysiloxanesDrug CarriersFluorescent DyesHydrophobic and Hydrophilic InteractionsNylonsDimethylpolysiloxanesDrug CarriersFluorescent DyesNylonspoly(dimethylsiloxane)-polyamide copolymerPolymerscancerdrug deliverylight-responsivemolecular motorpolymersome

Identifiers

PMID37364098
PMCPMC10319042

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.