Evidence map›Paper›PMID 37365313›Full record

ArticleNature neuroscience2023

Multi-level analysis of the gut-brain axis shows autism spectrum disorder-associated molecular and microbial profiles.

James T Morton, Dong-Min Jin, Robert H Mills, Yan Shao, Gibraan Rahman, Daniel McDonald, Qiyun Zhu, Metin Balaban, Yueyu Jiang, Kalen Cantrell and 33 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07381374 (Study Protocol for a Randomized Controlled of Fecal Microbiota Transplantation Via Different Routes in Children With Moderate-to-Severe Autism Spectrum Disorder), which is not on this map. Cited by 148 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
148citing papers in PubMed, 6 pooled it
29.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07381374 narecruitingnot on this mapstarted 2026, after this paper: background citation

Study Protocol for a Randomized Controlled of Fecal Microbiota Transplantation Via Different Routes in Children With Moderate-to-Severe Autism Spectrum Disorder

TypeinterventionalSponsorShenzhen Children's HospitalRan2026 to 2027Enrolled1ConditionsAutism Spectrum DisorderArmsctive FMT via Nasojejunal Tube (FMT-Upper GI), Active FMT via Colonoscopy and Transendoscopic Tube (FMT-Lower GI), Placebo via Sham Procedures (Sham-Control)
3 · Its place in the literature

Who cites it

148 citing papers in PubMed, 6 syntheses or guidelines pooled it, 190 citations in OpenAlex.

  1. Pooled it
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  9. Oral virome in health and disease.Journal of the American Dental Association (1939) · 2026
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88 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors at 20 institutions in 9 countries.

James T Morton *Center for Computational Biology, Flatiron Institute, Simons Foundation, New York, NY, USA.ORCID http://orcid.org/0000-0003-3189-2681
Dong-Min JinCenter for Genomics and Systems Biology, Department of Biology, New York University, New York, NY, USA.
Robert H MillsPrecidiag, Inc., Watertown, MA, USA.
Yan ShaoHost-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-8662-0504
Gibraan RahmanBioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA, USA.
Daniel McDonaldDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Qiyun ZhuSchool of Life Sciences, Arizona State University, Tempe, AZ, USA.
Metin BalabanBioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA, USA.
Yueyu JiangDepartment of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA, USA.
Kalen CantrellDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Antonio GonzalezDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Julie CarmelAzrieli Faculty of Medicine, Bar Ilan University, Safed, Israel.
Linoy Mia FrankiensztajnAzrieli Faculty of Medicine, Bar Ilan University, Safed, Israel.
Sandra Martin-BrevetLaboratory for Research in Neuroimaging, Centre for Research in Neurosciences, Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland.
Kirsten BerdingDivision of Nutritional Sciences, University of Illinois, Urbana, IL, USA.
Brittany D NeedhamStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0002-0280-1886
María Fernanda ZuritaMicrobiology Institute and Health Science College, Universidad San Francisco de Quito, Quito, Ecuador.ORCID http://orcid.org/0000-0001-7530-5624
Maude DavidDepartments of Microbiology & Pharmaceutical Sciences, Oregon State University, Corvallis, OR, USA.
Olga V AverinaVavilov Institute of General Genetics Russian Academy of Sciences, Moscow, Russia.
Alexey S KovtunVavilov Institute of General Genetics Russian Academy of Sciences, Moscow, Russia.
Antonio NotoDepartment of Biomedical Sciences, School of Medicine, University of Cagliari, Cagliari, Italy.ORCID http://orcid.org/0000-0003-3538-0050
Michele MussapLaboratory Medicine, Department of Surgical Sciences, School of Medicine, University of Cagliari, Cagliari, Italy.
Mingbang WangShanghai Key Laboratory of Birth Defects, Division of Neonatology, Children's Hospital of Fudan University, National Center for Children's Health, Shanghai, China.ORCID http://orcid.org/0000-0002-5989-5377
Daniel N FrankDepartment of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0001-6669-228X
Ellen LiDepartment of Medicine, Division of Gastroenterology and Hepatology, Stony Brook University, Stony Brook, NY, USA.ORCID http://orcid.org/0000-0002-1141-0406
Wenhao ZhouShanghai Key Laboratory of Birth Defects, Division of Neonatology, Children's Hospital of Fudan University, National Center for Children's Health, Shanghai, China.ORCID http://orcid.org/0000-0001-8956-7238
Vassilios FanosNeonatal Intensive Care Unit and Neonatal Pathology, Department of Surgical Sciences, School of Medicine, University of Cagliari, Cagliari, Italy.
Valery N DanilenkoVavilov Institute of General Genetics Russian Academy of Sciences, Moscow, Russia.
Dennis P WallPediatrics (Systems Medicine), Biomedical Data Science, and Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-7889-9146
Paúl CárdenasInstitute of Microbiology, COCIBA, Universidad San Francisco de Quito, Quito, Ecuador.ORCID http://orcid.org/0000-0001-9626-4489
Manuel E BaldeónFacultad de Ciencias Médicas, de la Salud y la Vida, Universidad Internacional del Ecuador, Quito, Ecuador.ORCID http://orcid.org/0000-0002-1243-7467
Sébastien JacquemontSainte Justine Hospital Research Center, Montréal, QC, Canada.ORCID http://orcid.org/0000-0001-6838-8767
Omry KorenAzrieli Faculty of Medicine, Bar Ilan University, Safed, Israel.
Evan ElliottAzrieli Faculty of Medicine, Bar Ilan University, Safed, Israel.ORCID http://orcid.org/0000-0002-1630-969X
Ramnik J XavierBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-5630-5167
Sarkis K MazmanianDivision of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0003-2713-1513
Rob KnightDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-0975-9019
Jack A GilbertDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-7920-7001
Sharon M DonovanDivision of Nutritional Sciences, University of Illinois, Urbana, IL, USA.
Trevor D LawleyHost-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-4805-621X
Bob CarpenterCenter for Computational Biology, Flatiron Institute, Simons Foundation, New York, NY, USA.
Richard BonneauCenter for Computational Biology, Flatiron Institute, Simons Foundation, New York, NY, USA.
Gaspar Taroncher-Oldenburg *Gaspar Taroncher Consulting, Philadelphia, PA, USA. gtaroncher@gmail.com.ORCID http://orcid.org/0000-0003-2840-1415
University of California San Diego · USBar-Ilan University · ILSimons Foundation · USUniversity of Cagliari · ITUniversidad San Francisco de Quito · ECUniversity of Illinois Urbana-Champaign · USVavilov Institute of General Genetics · RUWellcome Sanger Institute · GBArizona State University · USBroad Institute · USCalifornia Institute of Technology · USCentre Hospitalier Universitaire Sainte-Justine · CAChildren's Hospital of Fudan University · CNIndiana University School of MedicineNational Institutes of Health · USNew York University · USOregon State University · USScripps Institution of Oceanography · USShenzhen University Health Science Center · CNSkolkovo Institute of Science and Technology · RU

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 1991 to 2026
$35.3M
NIDDK NIH HHS P30 DK043351Wellcome TrustWellcome Trust WT206194
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by heterogeneous cognitive, behavioral and communication impairments. Disruption of the gut-brain axis (GBA) has been implicated in ASD although with limited reproducibility across studies. In this study, we developed a Bayesian differential ranking algorithm to identify ASD-associated molecular and taxa profiles across 10 cross-sectional microbiome datasets and 15 other datasets, including dietary patterns, metabolomics, cytokine profiles and human brain gene expression profiles. We found a functional architecture along the GBA that correlates with heterogeneity of ASD phenotypes, and it is characterized by ASD-associated amino acid, carbohydrate and lipid profiles predominantly encoded by microbial species in the genera Prevotella, Bifidobacterium, Desulfovibrio and Bacteroides and correlates with brain gene expression changes, restrictive dietary patterns and pro-inflammatory cytokine profiles. The functional architecture revealed in age-matched and sex-matched cohorts is not present in sibling-matched cohorts. We also show a strong association between temporal changes in microbiome composition and ASD phenotypes. In summary, we propose a framework to leverage multi-omic datasets from well-defined cohorts and investigate how the GBA influences ASD.

Indexed as

Autism Spectrum DisorderGastrointestinal MicrobiomeBayes TheoremBrain-Gut AxisCross-Sectional StudiesCytokinesHumansReproducibility of ResultsCytokines

Identifiers

PMID37365313
PMCPMC10322709
OpenAlexW4382139746

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.