Evidence map›Paper›PMID 37367012›Full record

ArticleBiosensors2023

A Label-Free and Antibody-Free Molecularly Imprinted Polymer-Based Impedimetric Sensor for NSCLC-Cells-Derived Exosomes Detection.

Jingbo Zhang, Quancheng Chen, Xuemin Gao, Qian Lin, Ziqin Suo, Di Wu, Xijie Wu, Qing Chen

Abstract read
In one paragraph

Article in Biosensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. An ultrasensitive sensing strategy based on CRISPR/Cas13a and T7 RNA polymerase amplification for detection of extracellular vesicles.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jingbo ZhangSchool of Pharmaceutical Science, Xiamen University, 4221 Xiang'an South Road, Xiamen 361102, China.ORCID 0000-0002-8663-9272
Quancheng ChenSchool of Pharmaceutical Science, Xiamen University, 4221 Xiang'an South Road, Xiamen 361102, China.
Xuemin GaoSchool of Pharmaceutical Science, Xiamen University, 4221 Xiang'an South Road, Xiamen 361102, China.
Qian LinSchool of Pharmaceutical Science, Xiamen University, 4221 Xiang'an South Road, Xiamen 361102, China.
Ziqin SuoSchool of Pharmaceutical Science, Xiamen University, 4221 Xiang'an South Road, Xiamen 361102, China.
Di WuSchool of Pharmaceutical Science, Xiamen University, 4221 Xiang'an South Road, Xiamen 361102, China.
Xijie WuDepartment of Cardiac Surgery, Xiamen Cardiovascular Hospital, Xiamen University, 2999 Jinshan Road, Xiamen 361010, China.
Qing ChenSchool of Pharmaceutical Science, Xiamen University, 4221 Xiang'an South Road, Xiamen 361102, China.ORCID 0000-0001-7301-1622

Funding

Education Department of Fujian Province JT180012Xiamen Municipal Bureau of Science and Technology 3502Z20206044
6 · The paper itself

Abstract

In this study, a label-free and antibody-free impedimetric biosensor based on molecularly imprinting technology for exosomes derived from non-small-cell lung cancer (NSCLC) cells was established. Involved preparation parameters were systematically investigated. In this design, with template exosomes anchored on a glassy carbon electrode (GCE) by decorated cholesterol molecules, the subsequent electro-polymerization of APBA and elution procedure afforded a selective adsorption membrane for template A549 exosomes. The adsorption of exosomes caused a rise in the impedance of the sensor, so the concentration of template exosomes can be quantified by monitoring the impedance of GCEs. Each procedure in the establishment of the sensor was monitored with a corresponding method. Methodological verification showed great sensitivity and selectivity of this method with an LOD = 2.03 × 10

Indexed as

Carcinoma, Non-Small-Cell LungExosomesLung NeoplasmsMolecular ImprintingAntibodiesElectrochemical TechniquesElectrodesHumansLimit of DetectionMolecularly Imprinted PolymersPolymersAntibodiesMolecularly Imprinted PolymersPolymersantibody-freeexosomesimpedimetric sensormolecular imprinted polymers (MIPs)

Identifiers

PMID37367012
PMCPMC10296324

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.