ArticleThe Plant cell2023
N4-acetylation of cytidine in mRNA plays essential roles in plants.
Article in The Plant cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 34 citations in OpenAlex.
- Advances in the study of the role of epigenetic mechanisms in plant growth and response to stress.Horticulture research · 2026Article
- RNA regulation in plants.Science China. Life sciences · 2026Review
- Epitranscriptomic profiling of cytosine N4 acetylation (acMolecular horticulture · 2026Article
- Emerging roles of non-mNature plants · 2026Review
- A comprehensive analysis of the use of nucleoside analogues in RNA therapeutics.Journal of translational medicine · 2026Review
- Emerging roles of mRNA acetylation in plants.Plant communications · 2026Article
- Review
- Advances in Detecting RNA Modifications Using Direct RNA Nanopore Sequencing.Advanced genetics (Hoboken, N.J.) · 2025Review
- Epitranscriptomic modifications in plant RNAs.RNA biology · 2025Review
- The emerging epitranscriptomic modification acNature plants · 2025Review
- Review
- Epigenetics in the modern era of crop improvements.Science China. Life sciences · 2025Review
- Comprehensive Analysis of Small RNA Modifications inMetabolites · 2025Article
- RNA modifications in plant adaptation to abiotic stresses.Plant communications · 2025Review
- Identification of the RNA m5C methyltransferase genes inForestry research · 2025Article
- Advances of NAT10 in diseases: insights from dual properties as protein and RNA acetyltransferase.Cell biology and toxicology · 2024Review
- Identification of Key Genes Involved in Seed Germination ofInternational journal of molecular sciences · 2024Article
- Deep learning modeling of RNA ac4C deposition reveals the importance of plant alternative splicing.Plant molecular biology · 2024Article
- Dynamics of epitranscriptomes uncover translational reprogramming directed by ac4C in rice during pathogen infection.Nature plants · 2024Article
- Endogenous γ-Aminobutyric Acid Accumulation Enhances Salinity Tolerance in Rice.Plants (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biological function of RNA can be modulated by base modifications. Here, we unveiled the occurrence of N4-acetylation of cytidine in plant RNA, including mRNA, by employing LC-MS/MS and acRIP-seq. We identified 325 acetylated transcripts from the leaves of 4-week-old Arabidopsis (Arabidopsis thaliana) plants and determined that 2 partially redundant N-ACETYLTRANSFERASEs FOR CYTIDINE IN RNA (ACYR1 and ACYR2), which are homologous to mammalian NAT10, are required for acetylating RNA in vivo. A double-null mutant was embryo lethal, while eliminating 3 of the 4 ACYR alleles led to defects in leaf development. These phenotypes could be traced back to the reduced acetylation and concomitant destabilization of the transcript of TOUGH, which is required for miRNA processing. These findings indicate that N4-acetylation of cytidine is a modulator of RNA function with a critical role in plant development and likely many other processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.