Evidence map›Paper›PMID 37368486›Full record

ReviewACS applied bio materials2023

Recent Advances in Nanotherapeutics for Neurological Disorders.

Arti Vashist, Pandiaraj Manickam, Andrea D Raymond, Adriana Yndart Arias, Nagesh Kolishetti, Atul Vashist, Emanuel Arias, Madhavan Nair

Open access · hybridAbstract readReview
In one paragraph

Review in ACS applied bio materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 55 citations in OpenAlex.

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  14. ISR Modulators in Neurological Diseases.Current neuropharmacology · 2025
    Review
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  19. Gold Nanoparticles in Neurological Diseases: A Review of Neuroprotection.International journal of molecular sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Arti VashistDepartment of Immunology and Nanomedicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, United States.ORCID 0000-0002-7519-1863
Pandiaraj ManickamElectrodics and Electrocatalysis Division, CSIR-Central Electrochemical Research Institute (CECRI), CSIR-CECRI Campus, Karaikudi, 630 003 Tamil Nadu, India.ORCID 0000-0001-7441-0545
Andrea D RaymondDepartment of Immunology and Nanomedicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, United States.
Adriana Yndart AriasDepartment of Immunology and Nanomedicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, United States.
Nagesh KolishettiDepartment of Immunology and Nanomedicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, United States.ORCID 0000-0001-5574-673X
Atul VashistDepartment of Infection & Immunology, Translational Health Science and Technology, Faridabad, 121001 Haryana, India.ORCID 0000-0002-2843-1166
Emanuel AriasDepartment of Immunology and Nanomedicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, United States.
Madhavan NairDepartment of Immunology and Nanomedicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, United States.
Florida International University · USCentral Electrochemical Research Institute · IN

Funding

Nanotechnology Based Gene Editing to Eradicate HIV Brain Reservoir in Drug AbusersR01DA042706 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI KHALILI, KAMEL, NAIR, MADHAVAN P. · 2016 to 2020
$3.2M
To evaluate the role of cannabinoid signaling during the comorbidity of HIV and Alzheimer¿s disease in the context of HIV-associated cognitive disordersR01DA040537 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI NAIR, MADHAVAN P. · 2015 to 2019
$3.0M
Targeting Inflammasome with stable endocannabinoid ligand AMG315. CRISPR/Cas9 and nanotechnology study in the context of HIV and cannabinoidR01DA052271 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI LAKSHMANA, MADEPALLI KRISHNAPPA, MAKRIYANNIS, ALEXANDROS · 2020 to 2024
$2.2M
Cocaine in the Neuropathogenesis of HIV infection: Role of HDAC2R01DA034547 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI NAIR, MADHAVAN P. · 2013 to 2018
$1.8M
Multifunctional Nanocarrier to Eradicate HIV from latently infected CNS cells andR01DA037838 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI NAIR, MADHAVAN P. · 2014 to 2018
$1.8M
NIDA NIH HHS R01 DA034547NIDA NIH HHS R01 DA037838NIDA NIH HHS R01 DA040537NIDA NIH HHS R01 DA042706NIDA NIH HHS R01 DA052271
6 · The paper itself

Abstract

Neurological disorders remain a significant health and economic burden worldwide. Addressing the challenges imposed by existing drugs, associated side- effects, and immune responses in neurodegenerative diseases is essential for developing better therapies. The immune activation in a diseased state has complex treatment protocols and results in hurdles for clinical translation. There is an immense need for the development of multifunctional nanotherapeutics with various properties to address the different limitations and immune interactions exhibited by the existing therapeutics. Nanotechnology has proven its potential to improve therapeutic delivery and enhance efficacy. Promising advancements have been made in developing nanotherapies that can be combined with CRISPR/Cas9 or siRNA for a targeted approach with unique potential for clinical translation. Engineering natural exosomes derived from mesenchymal stem cells (MSCs), dendritic cells (DCs), or macrophages to both deliver therapeutics and modulate the immune responses to tumors or in neurodegenerative disease (ND) can allow for targeted personalized therapeutic approaches. In the present review, we summarize and overview the recent advances in nanotherapeutics in addressing the existing treatment limitations and neuroimmune interactions for developing ND therapies and provide insights into the upcoming advancements in nanotechnology-based nanocarriers.

Indexed as

Drug Delivery SystemsNeurodegenerative DiseasesHumansNanotechnologyPharmaceutical PreparationsPharmaceutical PreparationsImmune interactionsNanomaterialsNanotechnologyNanotherapeuticsNeurological disorders

Identifiers

PMID37368486
PMCPMC10354745
OpenAlexW4382182033

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.