Evidence map›Paper›PMID 37370102›Full record

ArticleJournal of nanobiotechnology2023

Nano hydrogel-based oxygen-releasing stem cell transplantation system for treating diabetic foot.

Liangmiao Chen, Bingru Zheng, Yizhou Xu, Changzheng Sun, Wanrui Wu, Xiangpang Xie, Yu Zhu, Wei Cai, Suifang Lin, Ya Luo and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Liangmiao Chen *Department of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical University, 325200, Wenzhou, Zhejiang, China.
Bingru Zheng *Department of Interventional Vascular Surgery, The Third Affiliated Hospital of Wenzhou Medical University, No.108 Wansong Road, 325200, Wenzhou, Zhejiang, China.
Yizhou XuDepartment of Interventional Vascular Surgery, The Third Affiliated Hospital of Wenzhou Medical University, No.108 Wansong Road, 325200, Wenzhou, Zhejiang, China.
Changzheng SunInstitute of Cardiovascular Development and Translational Medicine, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, 325027, Wenzhou, Zhejiang, China.
Wanrui WuDepartment of Interventional Vascular Surgery, The Third Affiliated Hospital of Wenzhou Medical University, No.108 Wansong Road, 325200, Wenzhou, Zhejiang, China.
Xiangpang XieDepartment of Interventional Vascular Surgery, The Third Affiliated Hospital of Wenzhou Medical University, No.108 Wansong Road, 325200, Wenzhou, Zhejiang, China.
Yu ZhuDepartment of Interventional Vascular Surgery, The Third Affiliated Hospital of Wenzhou Medical University, No.108 Wansong Road, 325200, Wenzhou, Zhejiang, China.
Wei CaiDepartment of Interventional Vascular Surgery, The Third Affiliated Hospital of Wenzhou Medical University, No.108 Wansong Road, 325200, Wenzhou, Zhejiang, China.
Suifang LinDepartment of Interventional Vascular Surgery, The Third Affiliated Hospital of Wenzhou Medical University, No.108 Wansong Road, 325200, Wenzhou, Zhejiang, China.
Ya LuoDepartment of Interventional Vascular Surgery, The Third Affiliated Hospital of Wenzhou Medical University, No.108 Wansong Road, 325200, Wenzhou, Zhejiang, China. 381510869@qq.com.
Changsheng ShiDepartment of Interventional Vascular Surgery, The Third Affiliated Hospital of Wenzhou Medical University, No.108 Wansong Road, 325200, Wenzhou, Zhejiang, China. shichangsheng85@163.com.
Wenzhou Medical University · CNRuian People's Hospital · CNSecond Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University · CN

Funding

the Natural Science Foundation of Zhejiang Province LQ20H070001
6 · The paper itself

Abstract

The employment of stem cells and hydrogel is widespread in contemporary clinical approaches to treating diabetic foot ulcers. However, the hypoxic conditions in the surrounding lesion tissue lead to a low stem cell survival rate following transplantation. This research introduces a novel hydrogel with superior oxygen permeability and biocompatibility, serving as a vehicle for developing a stem cell transplantation system incorporating oxygen-releasing microspheres and cardiosphere-derived stem cells (CDCs). By optimizing the peroxidase fixation quantity on the microsphere surface and the oxygen-releasing microsphere content within the transplantation system, intracellular oxygen levels were assessed using electron paramagnetic resonance (EPR) under simulated low-oxygen conditions in vitro. The expression of vascularization and repair-related indexes were evaluated via RT-PCR and ELISA. The microspheres were found to continuously release oxygen for three weeks within the transplantation system, promoting growth factor expression to maintain intracellular oxygen levels and support the survival and proliferation of CDCs. Moreover, the effect of this stem cell transplantation system on wound healing in a diabetic foot mice model was examined through an in vivo animal experiment. The oxygen-releasing microspheres within the transplantation system preserved the intracellular oxygen levels of CDCs in the hypoxic environment of injured tissues. By inhibiting the expression of inflammatory factors and stimulating the upregulation of pertinent growth factors, it improved the vascularization of ulcer tissue on the mice's back and expedited the healing of the wound site. Overall, the stem cell transplantation system in this study, based on hydrogels containing CDCs and oxygen-releasing microspheres, offers a promising strategy for the clinical implementation of localized stem cell delivery to improve diabetic foot wound healing.

Indexed as

Diabetes MellitusDiabetic FootAnimalsHydrogelsIntercellular Signaling Peptides and ProteinsMiceOxygenStem Cell TransplantationWound HealingHydrogelsIntercellular Signaling Peptides and ProteinsOxygenDiabetic footHydrogelMicrospheresStem cellsTransplantation

Identifiers

PMID37370102
PMCPMC10294352
OpenAlexW4382344075

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.