Evidence map›Paper›PMID 37375374›Full record

ArticleMolecules (Basel, Switzerland)2023

Natural-Product-Inspired Microwave-Assisted Synthesis of Novel Spirooxindoles as Antileishmanial Agents: Synthesis, Stereochemical Assignment, Bioevaluation, SAR, and Molecular Docking Studies.

Nawal Kishore Sahu, Ritu Sharma, Kshirsagar Prasad Suhas, Jyoti Joshi, Kunal Prakash, Richa Sharma, Ramendra Pratap, Xiwen Hu, Sukhbir Kaur, Mukesh Jain and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nawal Kishore SahuLaboratory of Organic and Medicinal Chemistry (OMC Lab), Department of Chemistry, Malaviya National Institute of Technology, Jawaharlal Nehru Marg, Jaipur 302017, India.ORCID 0000-0002-1662-7348
Ritu SharmaLaboratory of Organic and Medicinal Chemistry (OMC Lab), Department of Chemistry, Malaviya National Institute of Technology, Jawaharlal Nehru Marg, Jaipur 302017, India.
Kshirsagar Prasad SuhasDepartment of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Raebareli (NIPER-R), New Transit Campus, Bijnor-Sisendi Road, Sarojini Nagar, Near CRPF Base Camp, Lucknow 226002, India.
Jyoti JoshiParasitology Laboratory, Department of Zoology, Panjab University, Chandigarh 160014, India.
Kunal PrakashDepartment of Chemistry, University of Delhi, North Campus, Delhi 110007, India.ORCID 0000-0002-2554-5416
Richa SharmaLaboratory of Organic and Medicinal Chemistry (OMC Lab), Department of Chemistry, Malaviya National Institute of Technology, Jawaharlal Nehru Marg, Jaipur 302017, India.
Ramendra PratapDepartment of Chemistry, University of Delhi, North Campus, Delhi 110007, India.ORCID 0000-0003-1846-1561
Xiwen HuSchool of Pharmacy, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, China.
Sukhbir KaurParasitology Laboratory, Department of Zoology, Panjab University, Chandigarh 160014, India.
Mukesh JainLaboratory of Organic and Medicinal Chemistry (OMC Lab), Department of Chemistry, Malaviya National Institute of Technology, Jawaharlal Nehru Marg, Jaipur 302017, India.
Carmine ColucciniInstitute of New Drug Development, College of Medicine, China Medical University, No. 91, Hsueh-Shih Road, Taichung 40402, Taiwan.
Paolo CoghiSchool of Pharmacy, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, China.ORCID 0000-0002-0015-1453
Sandeep ChaudharyLaboratory of Organic and Medicinal Chemistry (OMC Lab), Department of Chemistry, Malaviya National Institute of Technology, Jawaharlal Nehru Marg, Jaipur 302017, India.ORCID 0000-0002-1444-3895

Funding

Council of Scientific and Industrial Research 02(0286)/16/EMR-IIIndian Council of Medical Research 61/8/2O2O-IMM/BMSIndian Council of Medical Research BIC/12(03)/2014Macau University of Science and Technology FRG-22-077-SPMinistry of Science and Technology MOST 110-2113-M-039-001Ministry of Science and Technology MOST 111-2221-E-039-009Science and Engineering Research Board CRG/2019/005102
6 · The paper itself

Abstract

Leishmaniasis is a neglected tropical disease, and there is an emerging need for the development of effective drugs to treat it. To identify novel compounds with antileishmanial properties, a novel series of functionalized spiro[indoline-3,2'-pyrrolidin]-2-one/spiro[indoline-3,3'-pyrrolizin]-2-one

Indexed as

Antiprotozoal AgentsLeishmania donovaniCamptothecinMicrowavesMolecular Docking SimulationStructure-Activity RelationshipAntiprotozoal AgentsCamptothecinantileishmanial agentsmicrowave-assisted synthesismolecular docking studiesspirooxindolestructure–activity relationship

Identifiers

PMID37375374
PMCPMC10302753

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.