Evidence map›Paper›PMID 37375594›Full record

Trial reportNutrients2023

Multivitamin/Multimineral Supplementation Prevents or Reverses Decline in Vitamin Biomarkers and Cellular Energy Metabolism in Healthy Older Men: A Randomized, Double-Blind, Placebo-Controlled Study.

Alexander J Michels, Judy A Butler, Sandra L Uesugi, Ken Lee, Balz B Frei, Gerd Bobe, Kathy R Magnusson, Tory M Hagen

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03004807 (Role of Centrum® Silver® in Improving Micronutrient Status in Older Men), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03004807 nacompletednot on this map

Role of Centrum® Silver® in Improving Micronutrient Status in Older Men

TypeinterventionalSponsorOregon State UniversityRan2018 to 2021Enrolled41ConditionsVitamin Deficiency, Mineral Deficiency, AgingArmsCentrum Silver Mens' Formula, Control
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Alexander J MichelsLinus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.ORCID 0000-0003-4528-7976
Judy A ButlerLinus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.
Sandra L UesugiLinus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.
Ken LeeLinus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.
Balz B FreiLinus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.
Gerd BobeLinus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.ORCID 0000-0002-3129-5628
Kathy R MagnussonLinus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.
Tory M HagenLinus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.
Oregon State University · US

Funding

Triphenylphosphonium-glutathione as a Protectant Against Mitochondrial DecayR21AG060206 · NIA · OREGON STATE UNIVERSITY · PI HAGEN, TORY M · 2019 to 2020
$407k
NIA NIH HHS 5R21AG060206-02NIA NIH HHS R21 AG060206
6 · The paper itself

Abstract

Despite the reported prevalence of micronutrient deficiencies in older adults, it is not yet established whether multivitamin/multimineral (MV/MM) supplements improve blood micronutrient status in individuals over the age of 65. Therefore, a cohort of 35 healthy men (>67 years) was recruited for an MV/MM supplementation trial. The primary endpoint was, as an indicator of micronutrient status, changes in blood micronutrient biomarkers from baseline to at least six months of supplementation with MV/MM or placebo. The secondary endpoint was basal O

Indexed as

Trace ElementsVitaminsAgedBiomarkersDietary SupplementsDouble-Blind MethodEnergy MetabolismHumansMaleMicronutrientsMineralsBiomarkersMicronutrientsMineralsTrace ElementsVitaminsdietary supplementshealthy agingmicronutrient statusmineralmultivitaminO2 consumptionvitamin

Identifiers

PMID37375594
PMCPMC10301451
OpenAlexW4380085979

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.