Evidence map›Paper›PMID 37375729›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Diversity of Solid Forms Promoted by Ball Milling: Characterization and Intrinsic Dissolution Studies of Pioglitazone Hydrochloride and Fluvastatin Sodium Drug-Drug Systems.

Marco Villeda-Villegas, José C Páez-Franco, Guadalupe Coyote-Dotor, Alejandra Núñez-Pineda, Alejandro Dorazco-González, Inés Fuentes-Noriega, Kenneth Rubio-Carrasco, Helen P Toledo Jaldín, David Morales-Morales, Juan Manuel Germán-Acacio

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marco Villeda-VillegasRed de Apoyo a la Investigación, Coordinación de la Investigación Científica-UNAM, Instituto Nacional de Ciencias Médicas y Nutrición SZ, Ciudad de Mexico 14000, Mexico.
José C Páez-FrancoRed de Apoyo a la Investigación, Coordinación de la Investigación Científica-UNAM, Instituto Nacional de Ciencias Médicas y Nutrición SZ, Ciudad de Mexico 14000, Mexico.
Guadalupe Coyote-DotorRed de Apoyo a la Investigación, Coordinación de la Investigación Científica-UNAM, Instituto Nacional de Ciencias Médicas y Nutrición SZ, Ciudad de Mexico 14000, Mexico.
Alejandra Núñez-PinedaCentro Conjunto de Investigación en Química Sustentable CCIQS UAEM-UNAM Carretera Toluca-Atlacomulco km 14.5, Toluca 50200, Mexico.
Alejandro Dorazco-GonzálezInstituto de Química, Universidad Nacional Autónoma de Mexico, Circuito Exterior, Ciudad Universitaria, Ciudad de Mexico 04510, Mexico.ORCID 0000-0002-7056-4237
Inés Fuentes-NoriegaLaboratorio de Biofarmacia, Departamento de Farmacia, Facultad de Química-UNAM, Ciudad de México 04510, Mexico.
Kenneth Rubio-CarrascoLaboratorio de Biofarmacia, Departamento de Farmacia, Facultad de Química-UNAM, Ciudad de México 04510, Mexico.
Helen P Toledo JaldínTechnological Superior Studies Tianguistenco, Mechanical Engineering, Santiago Tianguistenco 52650, Mexico.
David Morales-MoralesInstituto de Química, Universidad Nacional Autónoma de Mexico, Circuito Exterior, Ciudad Universitaria, Ciudad de Mexico 04510, Mexico.ORCID 0000-0002-7984-1819
Juan Manuel Germán-AcacioRed de Apoyo a la Investigación, Coordinación de la Investigación Científica-UNAM, Instituto Nacional de Ciencias Médicas y Nutrición SZ, Ciudad de Mexico 14000, Mexico.ORCID 0000-0002-5915-2944

Funding

PAPIIT-DGAPA-UNAM IT200920
6 · The paper itself

Abstract

Coamorphous salt in a 1:1 ratio prepared by ball milling from Fluvastatin sodium (FLV) and Pioglitazone hydrochloride (PGZ·HCl) can be selectively formed by neat grinding (NG). Furthermore, the salt-cocrystal continuum was preferably formed by employing liquid-assisted grinding (LAG) using ethanol (EtOH). Attempts to prepare the coamorphous salt starting from the salt-cocrystal continuum by NG were unsuccessful. Interestingly, through ball milling by NG or LAG, a great diversity of solid forms (PGZ·HCl-FLV 1:1) could be accessed: NG and hexane (coamorphous); ethyl acetate (physical mixture); EtOH (salt-cocrystal continuum); and water (which presents two T

Indexed as

drug–drug coamorphousdrug–drug salt–cocrystal continuumfluvastatin sodiumintrinsic dissolution experimentsmechanochemical reactionspioglitazone hydrochlorideXPS experiments

Identifiers

PMID37375729
PMCPMC10303448

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.