ReviewPharmaceuticals (Basel, Switzerland)2023
Extra-Gonadal and Non-Canonical Effects of FSH in Males.
Review in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Iron overload disorders in adults: a comprehensive review of gonadal function, reproductive, and sexual health.Human reproduction update · 2026Pooled it
- Steatosis indices and penile vascular health: a metabolic association linking liver and vascular phenotypes.Journal of endocrinological investigation · 2026Article
- Is Follicle-Stimulating Hormone (FSH) Misnamed? Rethinking Its Role in Menopause as a Systemic Regulator of Bone, Brain, Metabolism, and Aging.Journal of clinical medicine · 2026Review
- Body composition in male hypogonadism: practical considerations to the use of dual-energy x-ray absorptiometry.Reviews in endocrine & metabolic disorders · 2026Review
- Association Between Serum Follicle-Stimulating Hormone Levels and Risk of Diabetes in Middle-Aged Men: A Long-Term Population-Based Longitudinal Study.Endocrinology, diabetes & metabolism · 2026Article
- Review
- Body Composition by DXA in Patients with Klinefelter and Kallmann Syndrome: The Kama Study.The Journal of clinical endocrinology and metabolism · 2026Observational
- The association between serum follicle-stimulating hormone and luteinizing hormone levels and congestive heart failure in postmenopausal women: a cross-sectional study.Scientific reports · 2026Article
- Functional data analysis of FSH and inhibin B levels in four ovulatory cycles shows a changing oscillatory interaction during the follicular phase.Frontiers in endocrinology · 2026Article
- Adverse histological features are more commonly observed in hypergonadotropic prostate cancer patients.The Canadian journal of urology · 2025Article
- Total and free testosterone as independent predictors of metabolic syndrome in U.S. Men: evidence from NHANES.Endocrine · 2025Article
- Review
- Expression and correlation of male reproductive hormone levels with abnormal semen liquefaction time.Annals of medicine · 2025Article
- Male Infertility and Reduced Life Expectancy: Epidemiology, Mechanisms, and Clinical Implications.Journal of clinical medicine · 2025Review
- A systematic review and meta-analysis of follicle-stimulating hormone levels among men with type 2 diabetes.Basic and clinical andrology · 2025Review
- Short-term effects of follicle-stimulating hormone on immune function, lipid, and vitamin metabolism in transiently castrated men.Endocrine connections · 2025Article
- FSH Therapy in Male Factor Infertility: Evidence and Factors Which Might Predict the Response.Life (Basel, Switzerland) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recombinant follicle-stimulating hormone (FSH) is commonly used for the treatment of female infertility and is increasingly being used in males as well, as recommended by notable guidelines. FSH is composed of an α subunit, shared with other hormones, and a β subunit, which confers specificity of biological action by interacting with its surface receptor (FSHR), predominantly located in granulosa and Sertoli cells. However, FSHRs also exist in extra-gonadal tissues, indicating potential effects beyond male fertility. Emerging evidence suggests that FSH may have extra-gonadal effects, including on bone metabolism, where it appears to stimulate bone resorption by binding to specific receptors on osteoclasts. Additionally, higher FSH levels have been associated with worse metabolic and cardiovascular outcomes, suggesting a possible impact on the cardiovascular system. FSH has also been implicated in immune response modulation, as FSHRs are expressed on immune cells and may influence inflammatory response. Furthermore, there is growing interest in the role of FSH in prostate cancer progression. This paper aims to provide a comprehensive analysis of the literature on the extra-gonadal effects of FSH in men, with a focus on the often-conflicting results reported in this field. Despite the contradictory findings, the potential for future development in this area is substantial, and further research is needed to elucidate the mechanisms underlying these effects and their clinical implications.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.