Evidence map›Paper›PMID 37377426›Full record

ArticleBiochemistry2023

Dual Noncanonical Amino Acid Incorporation Enabling Chemoselective Protein Modification at Two Distinct Sites in Yeast.

Priyanka Lahiri, Meghan S Martin, Briana R Lino, Rebecca A Scheck, James A Van Deventer

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Priyanka LahiriChemical and Biological Engineering Department, Tufts University, Medford, Massachusetts 02155, United States.ORCID 0000-0002-6971-1500
Meghan S MartinChemistry Department, Tufts University, Medford, Massachusetts 02155, United States.ORCID 0009-0006-9688-1309
Briana R LinoChemical and Biological Engineering Department, Tufts University, Medford, Massachusetts 02155, United States.ORCID 0009-0009-7141-4845
Rebecca A ScheckChemistry Department, Tufts University, Medford, Massachusetts 02155, United States.ORCID 0000-0003-0916-0572
James A Van DeventerChemical and Biological Engineering Department, Tufts University, Medford, Massachusetts 02155, United States.ORCID 0000-0003-4343-6157
Tufts University · US

Funding

The yeast surface as a platform for inhibitor discoveryR35GM133471 · NIGMS · TUFTS UNIVERSITY MEDFORD · PI James Allen Van Deventer · 2019 to 2026
$3.1M
The Chemistry and Biology of Protein GlycationR01GM132422 · NIGMS · TUFTS UNIVERSITY MEDFORD · PI SCHECK, REBECCA · 2020 to 2023
$1.2M
NIGMS NIH HHS R01 GM132422NIGMS NIH HHS R35 GM133471
6 · The paper itself

Abstract

Incorporation of more than one noncanonical amino acid (ncAA) within a single protein endows the resulting construct with multiple useful features such as augmented molecular recognition or covalent cross-linking capabilities. Herein, for the first time, we demonstrate the incorporation of two chemically distinct ncAAs into proteins biosynthesized in

Indexed as

Amino Acyl-tRNA SynthetasesSaccharomyces cerevisiaeAmino AcidsCodon, TerminatorGenetic CodeProteinsAmino AcidsAmino Acyl-tRNA SynthetasesCodon, TerminatorProteins

Identifiers

PMID37377426
PMCPMC11146674
OpenAlexW4382344905

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.