ArticlePLoS computational biology2023
Laminar specificity of the auditory perceptual awareness negativity: A biophysical modeling study.
Article in PLoS computational biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 16 citations in OpenAlex.
- Predictive acoustical processing in human cortical layers.Nature communications · 2026Article
- Uncovering putative neural mechanisms of neurotherapeutic impacts on EEG using the Human Neocortical Neurosolver.bioRxiv : the preprint server for biology · 2026Article
- Testing circuit-level theories of consciousness in humans.Trends in cognitive sciences · 2026Review
- Cross-spatial scale processing of hierarchical auditory sequences in human brains revealed using 7 T magnetic resonance imaging.Nature communications · 2025Article
- Inter-Stimulus-Interval Dependence in Auditory Cortex Reflects Perceptual Organization of Streams Under Informational Masking.Psychophysiology · 2025Article
- Neurophysiology of mismatch negativity generation: a biophysical modeling study.bioRxiv : the preprint server for biology · 2025Article
- Tactile stimulations reduce or promote the segregation of auditory streams: psychophysics and modeling.PLoS computational biology · 2025Article
- A burst-dependent thalamocortical substrate for perceptual awareness.PLoS computational biology · 2025Article
- Perceptual awareness of near-threshold tones scales gradually with auditory cortex activity and pupil dilation.iScience · 2024Article
- Review
- Isolating Neural Signatures of Conscious Speech Perception with a No-Report Sine-Wave Speech Paradigm.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Cellular mechanisms of cooperative context-sensitive predictive inference.Current research in neurobiology · 2024Review
- The auditory P2 is influenced by pitch changes but not pitch strength and consists of two separate subcomponents.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- HNN-core: A Python software for cellular and circuit-level interpretation of human MEG/EEG.Journal of open source software · 2023Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
How perception of sensory stimuli emerges from brain activity is a fundamental question of neuroscience. To date, two disparate lines of research have examined this question. On one hand, human neuroimaging studies have helped us understand the large-scale brain dynamics of perception. On the other hand, work in animal models (mice, typically) has led to fundamental insight into the micro-scale neural circuits underlying perception. However, translating such fundamental insight from animal models to humans has been challenging. Here, using biophysical modeling, we show that the auditory awareness negativity (AAN), an evoked response associated with perception of target sounds in noise, can be accounted for by synaptic input to the supragranular layers of auditory cortex (AC) that is present when target sounds are heard but absent when they are missed. This additional input likely arises from cortico-cortical feedback and/or non-lemniscal thalamic projections and targets the apical dendrites of layer-5 (L5) pyramidal neurons. In turn, this leads to increased local field potential activity, increased spiking activity in L5 pyramidal neurons, and the AAN. The results are consistent with current cellular models of conscious processing and help bridge the gap between the macro and micro levels of perception-related brain activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.