Evidence map›Paper›PMID 37385580›Full record

ArticleJournal of molecular biology2023

Influence of HIV-1 Genomic RNA on the Formation of Gag Biomolecular Condensates.

Anne Monette, Meijuan Niu, Rebecca Kaddis Maldonado, Jordan Chang, Gregory S Lambert, John M Flanagan, Alan Cochrane, Leslie J Parent, Andrew J Mouland

Open access · greenAbstract read
In one paragraph

Article in Journal of molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Anne MonetteLady Davis Institute at the Jewish General Hospital, Montréal, Québec H3T 1E2, Canada.
Meijuan NiuLady Davis Institute at the Jewish General Hospital, Montréal, Québec H3T 1E2, Canada.
Rebecca Kaddis MaldonadoDepartment of Medicine, Pennsylvania State University College of Medicine, Hershey, PA 17033, United States; Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, United States.
Jordan ChangDepartment of Medicine, Pennsylvania State University College of Medicine, Hershey, PA 17033, United States.
Gregory S LambertDepartment of Medicine, Pennsylvania State University College of Medicine, Hershey, PA 17033, United States.
John M FlanaganDepartment of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, PA 17033, United States.
Alan CochraneDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Leslie J ParentDepartment of Medicine, Pennsylvania State University College of Medicine, Hershey, PA 17033, United States; Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, United States. Electronic address: lparent@pennstatehealth.psu.edu.
Andrew J MoulandLady Davis Institute at the Jewish General Hospital, Montréal, Québec H3T 1E2, Canada; Department of Medicine, McGill University, Montréal, Québec H4A 3J1, Canada. Electronic address: andrew.mouland@mcgill.ca.
Pennsylvania State University · USJewish General Hospital · CAUniversity of Toronto · CA

Funding

Role of biomolecular condensates in regulating HIV-1 viral ribonucleoprotein complex formation in the setting of substance use disorderR33DA053689 · NIDA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI PARENT, LESLIE J · 2023 to 2025
$1.1M
Role of biomolecular condensates in regulating HIV-1 viral ribonucleoprotein complex formation in the setting of substance use disorderR21DA053689 · NIDA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI PARENT, LESLIE J · 2021 to 2022
$360k
NIDA NIH HHS R21 DA053689NIDA NIH HHS R33 DA053689
6 · The paper itself

Abstract

Biomolecular condensates (BMCs) play an important role in the replication of a growing number of viruses, but many important mechanistic details remain to be elucidated. Previously, we demonstrated that the pan-retroviral nucleocapsid (NC) and HIV-1 pr55

Indexed as

Biomolecular Condensatesgag Gene Products, Human Immunodeficiency VirusHIV-1Host-Pathogen InteractionsRNA, ViralVirus AssemblyGenome, ViralHumansgag Gene Products, Human Immunodeficiency VirusRNA, Viralbiomolecular condensatesgag polyproteinhuman immunodeficiency virus-type 1phase diagramsviral genomic RNA

Identifiers

PMID37385580
PMCPMC10838171
OpenAlexW4382199947

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.