ArticleScientific reports2023
Resistant starches from dietary pulses modulate the gut metabolome in association with microbiome in a humanized murine model of ageing.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Nutraceutical Blends Promote Weight Loss, Inflammation Reduction, and Better Sleep: The Role of Faecalibacterium prausnitzii in Overweight Adults-A Double-Blind Trial.Molecular nutrition & food research · 2025Trial
- Nutraceutical blends predict enhanced health via microbiota reshaping improving cytokines and life quality: a Brazilian double-blind randomized trial.Scientific reports · 2024Trial
- Maternal diet shapes neonatal microbiome ontogenesis and neurometabolic resilience.Gut microbes · 2026Article
- Lentil-Derived Bioactives for Gastrointestinal Health: Potential Complementary Interactions Among Peptides, Resistant Starch, and Polyphenols.Nutrients · 2026Review
- Intestinal microbial community assessment in patients with different forms of epilepsy and autoimmune encephalitis: An exploratory study.Gut microbes reports · 2026Article
- Obesity-associated gut microbiome influences diet-induced metabolic and cognitive outcomes in older adults.Gut microbes reports · 2026Article
- How the Intake of Pulses May Impact Metabolic Disorders and Dementia Risk: A Narrative Review.Nutrients · 2025Review
- Microbiome-based therapeutics towards healthier aging and longevity.Genome medicine · 2025Review
- Analysis of Human Gut Microbiota Enzymes for Biotechnological and Food Industrial Applications.Foods (Basel, Switzerland) · 2025Article
- Role of Lactobacillus plantarum-Derived Extracellular Vesicles in Regulating Alcohol Consumption.Molecular neurobiology · 2025Article
- Treatment of Acute Ulcerative Colitis with Zinc Hyaluronate in Mice.Journal of microbiology and biotechnology · 2025Article
- Article
- An Enteric Bacterial Infection Triggers Neuroinflammation and Neurobehavioral Impairment in 3xTg-AD Transgenic Mice.The Journal of infectious diseases · 2024Article
- Evaluation of synbiotic combinations of commercial probiotic strains with different prebiotics in in vitro and ex vivo human gut microcosm model.Archives of microbiology · 2024Article
- Standard rodent diets differentially impact alcohol consumption and preference and gut microbiome diversity.bioRxiv : the preprint server for biology · 2024Article
- Microbial Ecology and Metabolism of Emerging Adulthood: Gut Microbiome Insights from a College Freshman Cohort.Gut microbes reports · 2024Article
- Standard rodent diets differentially impact alcohol consumption, preference, and gut microbiome diversity.Frontiers in neuroscience · 2024Article
- Resistant starches from dietary pulses improve neurocognitive health via gut-microbiome-brain axis in aged mice.Frontiers in nutrition · 2024Article
- Understanding the Gut-Brain Axis and Its Therapeutic Implications for Neurodegenerative Disorders.Nutrients · 2023Review
- A modified Mediterranean-style diet enhances brain function via specific gut-microbiome-brain mechanisms.Gut microbesArticle
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emerging evidence suggests that plant-based fiber-rich diets improve ageing-associated health by fostering a healthier gut microbiome and microbial metabolites. However, such effects and mechanisms of resistant starches from dietary pulses remain underexplored. Herein, we examine the prebiotic effects of dietary pulses-derived resistant starch (RS) on gut metabolome in older (60-week old) mice carrying a human microbiome. Gut metabolome and its association with microbiome are examined after 20-weeks feeding of a western-style diet (control; CTL) fortified (5% w/w) with RS from pinto beans (PTB), black-eyed-peas (BEP), lentils (LEN), chickpeas (CKP), or inulin (INU; reference control). NMR spectroscopy-based untargeted metabolomic analysis yield differential abundance linking phenotypic differences in specific metabolites among different RS groups. LEN and CKP increase butyrate, while INU promotes propionate. Conversely, bile acids and cholesterol are reduced in prebiotic groups along with suppressed choline-to-trimethylamine conversion by LEN and CKP, whereas amino acid metabolism is positively altered. Multi-omics microbiome-metabolome interactions reveal an association of beneficial metabolites with the Lactobacilli group, Bacteroides, Dubosiella, Parasutterella, and Parabacteroides, while harmful metabolites correlate with Butyricimonas, Faecalibaculum, Colidextribacter, Enterococcus, Akkermansia, Odoribacter, and Bilophila. These findings demonstrate the functional effects of pulses-derived RS on gut microbial metabolism and their beneficial physiologic responses in an aged host.
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