Evidence map›Paper›PMID 37388753›Full record

ArticleSovremennye tekhnologii v meditsine2023

Effect of the Peptide Calcium Channel Blocker ω-hexatoxin-Hv1a on Cell Death during Ischemia/Reperfusion

E V Iurova, E A Beloborodov, Yu V Saenko, D E Sugak, A N Fomin, S M Slesarev, Ye S Pogodina

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sovremennye tekhnologii v meditsine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

E V IurovaJunior Researcher, Laboratory of Research and Development of Peptide Drugs and Vaccines, S.P. Kapitsa Technological Research Institute; Ulyanovsk State University, 42 Leo Tolstoy St., Ulyanovsk, 432017, Russia.
E A BeloborodovResearcher, Laboratory of Research and Development of Peptide Drugs and Vaccines, S.P. Kapitsa Technological Research Institute; Ulyanovsk State University, 42 Leo Tolstoy St., Ulyanovsk, 432017, Russia.
Yu V SaenkoLeading Researcher, Laboratory of Research and Development of Peptide Drugs and Vaccines, S.P. Kapitsa Technological Research Institute; Ulyanovsk State University, 42 Leo Tolstoy St., Ulyanovsk, 432017, Russia.
D E SugakJunior Researcher, Laboratory of Research and Development of Peptide Drugs and Vaccines, S.P. Kapitsa Technological Research Institute; Ulyanovsk State University, 42 Leo Tolstoy St., Ulyanovsk, 432017, Russia.
A N FominSenior Researcher, Director of the S.P. Kapitsa Technological Research Institute; Ulyanovsk State University, 42 Leo Tolstoy St., Ulyanovsk, 432017, Russia.
S M SlesarevProfessor, Head of the Department of Biology, Ecology and Nature Management, Institute of Medicine, Ecology and Physical Education; Ulyanovsk State University, 42 Leo Tolstoy St., Ulyanovsk, 432017, Russia.
Ye S PogodinaHead of the Laboratory of Research and Development of Peptide Drugs and Vaccines, S.P. Kapitsa Technological Research Institute Ulyanovsk State University, 42 Leo Tolstoy St., Ulyanovsk, 432017, Russia.
Moscow Technological Institute · RUUlyanovsk State University · RU

Funding

Ministry of Science and Higher Education of the Russian Federation .FEUF-2022-0008
6 · The paper itself

Abstract

Apoptosis and necrosis during reperfusion after ischemia are key mechanisms at the cellular level leading to damage. The development of pathological conditions is preceded by intracellular calcium ion overload both at the stage of ischemia and at the stage of reperfusion. In this regard, one of the strategies aimed at reducing damage during ischemia/reperfusion is associated with the use of calcium channel blockers. Materials and Methods: In this study, we used CHO-K1 epithelial cell culture. Changes in apoptosis, necrosis, cell index, and calcium ion concentration were assessed when modeling ischemia/reperfusion processes Results: An increase in apoptosis, necrosis, and the concentration of calcium ions was recorded when modeling ischemia/reperfusion processes. A decrease in the level of apoptosis and necrosis, as well as the concentration of calcium ions to a physiological level or a level close to physiological, was noted when the toxin was added at a concentration of 50 nM at the reperfusion stage. The cell index showed a faster restoration in the presence of the toxin. Conclusion: The experimental data confirm the hypothesis of a beneficial effect of peptide calcium channel blockers on the state of epithelial cells during reperfusion after ischemia and can be considered for further study as a strategy for organ adaptation before reperfusion.

Indexed as

Calcium Channel BlockersIschemiaCell DeathHumansNecrosisReperfusionCalcium Channel Blockersapoptosis during reperfusioncalcium channel blockersischemiapeptide toxinsreperfusion injury

Identifiers

PMID37388753
PMCPMC10306959
OpenAlexW4322627856

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.