Evidence map›Paper›PMID 37388915›Full record

ArticleCell genomics2023

Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis.

Andrew C Brown, Carla J Cohen, Olga Mielczarek, Gabriele Migliorini, Félicie Costantino, Alice Allcock, Connor Davidson, Katherine S Elliott, Hai Fang, Alicia Lledó Lara and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Andrew C BrownWellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Carla J CohenWellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Olga MielczarekWellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Gabriele MiglioriniWellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Félicie CostantinoWellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Alice AllcockWellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Connor DavidsonWellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Katherine S ElliottWellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Hai FangWellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Alicia Lledó LaraWellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Alice C MartinWellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Julie A OsgoodWellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Anna SannitiWellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Giuseppe ScozzafavaWellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Matteo VecellioNuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK.
Ping ZhangWellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Mary Helen BlackData Science, Population Analytics, Janssen R&D, Spring House, PA 19002, USA.
Shuwei LiData Science, Population Analytics, Janssen R&D, Spring House, PA 19002, USA.
Dongnhu TruongData Science, Population Analytics, Janssen R&D, Spring House, PA 19002, USA.
Julio MolinerosData Science, Population Analytics, Janssen R&D, Spring House, PA 19002, USA.
Trevor HoweData Science, External Innovation, Janssen R&D, London W1G 0BG, UK.
B Paul WordsworthNuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK.
Paul BownessNuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK.
Julian C KnightWellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Ankylosing spondylitis (AS) is a common, highly heritable inflammatory arthritis characterized by enthesitis of the spine and sacroiliac joints. Genome-wide association studies (GWASs) have revealed more than 100 genetic associations whose functional effects remain largely unresolved. Here, we present a comprehensive transcriptomic and epigenomic map of disease-relevant blood immune cell subsets from AS patients and healthy controls. We find that, while CD14

Indexed as

ankylosing spondylitischromatin interactionsepigenomicsfunctional genomicsgene regulationgenome-wide association studyspondyloarthritistarget discoverytranscriptomics

Identifiers

PMID37388915
PMCPMC10300554

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.