Evidence map›Paper›PMID 37389440›Full record

ArticleAnalytical chemistry2023

Assessment of a 60-Biomarker Health Surveillance Panel (HSP) on Whole Blood from Remote Sampling Devices by Targeted LC/MRM-MS and Discovery DIA-MS Analysis.

Stephen A Whelan, Nathan Hendricks, Zachary L Dwight, Qin Fu, Annie Moradian, Jennifer E Van Eyk, Susan M Mockus

Open access · hybridAbstract read
In one paragraph

Article in Analytical chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Stephen A WhelanPrecision Biomarker Laboratories, Cedars-Sinai Medical Center, Beverly Hills, California 90210, United States.ORCID 0000-0002-5439-6501
Nathan HendricksPrecision Biomarker Laboratories, Cedars-Sinai Medical Center, Beverly Hills, California 90210, United States.
Zachary L DwightPrecision Biomarker Laboratories, Cedars-Sinai Medical Center, Beverly Hills, California 90210, United States.
Qin FuSmidt Heart Institute, Advanced Clinical Biosystems Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, United States.ORCID 0000-0001-9056-8449
Annie MoradianPrecision Biomarker Laboratories, Cedars-Sinai Medical Center, Beverly Hills, California 90210, United States.ORCID 0000-0002-0407-2031
Jennifer E Van EykPrecision Biomarker Laboratories, Cedars-Sinai Medical Center, Beverly Hills, California 90210, United States.ORCID 0000-0001-9050-148X
Susan M MockusPrecision Biomarker Laboratories, Cedars-Sinai Medical Center, Beverly Hills, California 90210, United States.
Cedars-Sinai Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Telehealth, accessing healthcare and wellness remotely, should be a cost-effective and efficient way for individuals to receive care. The convenience of having a reliable remote collection device for blood tests will facilitate access to precision medicine and healthcare. Herein, we tested a 60-biomarker health surveillance panel (HSP), containing 35 FDA/LDT assays and covering at least 14 pathological states, on 8 healthy individuals' ability to collect their own capillary blood from a lancet finger prick and directly compared it to the traditional phlebotomist venous blood and plasma collection methods. All samples were spiked with 114 stable-isotope-labeled (SIL) HSP peptides and quantitatively analyzed by liquid chromatography-multiple reaction monitoring-mass spectrometry (LC/MRM-MS) scheduled method targeting 466 transitions from 114 HSP peptides and by a discovery data-independent acquisition mass spectrometry (DIA-MS) method. The average peak area ratio (PAR) of the HSP quantifier peptide transitions from all 8 volunteers' capillary blood (

Indexed as

Blood Specimen CollectionPeptidesBiomarkersChromatography, LiquidHumansMass SpectrometryBiomarkersPeptides

Identifiers

PMID37389440
PMCPMC10372875
OpenAlexW4382631852

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.