Evidence map›Paper›PMID 37389954›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2023

Bedding as a variable affecting fasting blood glucose and vascular physiology in mice.

Timothy M Sveeggen, Brant E Isakson, Adam C Straub, Pooneh Bagher

Abstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Analysis of IVC Microenvironments During an Extended Cage-Change Interval in Rats (Rattus norvegicus).Journal of the American Association for Laboratory Animal Science : JAALAS · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Timothy M SveeggenCellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska, United States.ORCID 0000-0003-2120-2165
Brant E IsaksonDepartment of Molecular Physiology and Biophysics, University of Virginia School of Medicine, Charlottesville, Virginia, United States.ORCID 0000-0002-7692-6294
Adam C StraubDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States.ORCID 0000-0003-0542-9466
Pooneh BagherCellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska, United States.ORCID 0000-0002-9778-6200

Funding

Basic and Translational Studies in Redox Regulation of Cardiovascular Physiology and DiseaseR35HL161177 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Adam Carl Straub · 2022 to 2026
$4.7M
Purinergic Regulation of Veinous Endothelial PermeabilityR01HL137112 · NHLBI · UNIVERSITY OF VIRGINIA · PI Brant E Isakson, MICHAEL H. KOVAL · 2018 to 2026
$4.7M
Mechanisms of Heterocellular Signaling at the Myoenothelial JunctionR01HL088554 · NHLBI · UNIVERSITY OF VIRGINIA · PI ISAKSON, BRANT E, WEISS, MITCHELL J · 2008 to 2017
$3.8M
The role of hemoglobin alpha in diabetes-related vascular dysfunctionR01HL155618 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BAGHER, POONEH · 2021 to 2025
$2.5M
NHLBI NIH HHS R01 HL088554NHLBI NIH HHS R01 HL137112NHLBI NIH HHS R01 HL155618NHLBI NIH HHS R35 HL161177
6 · The paper itself

Abstract

Rodent husbandry requires careful consideration of environmental factors that may impact colony performance and subsequent physiological studies. Of note, recent reports have suggested corncob bedding may affect a broad range of organ systems. As corncob bedding may contain digestible hemicelluloses, trace sugars, and fiber, we hypothesized that corncob bedding impacts overnight fasting blood glucose and murine vascular function. Here, we compared mice housed on corncob bedding, which were then fasted overnight on either corncob or ALPHA-dri bedding, a virgin paper pulp cellulose alternative. Male and female mice were used from two noninduced, endothelial-specific conditional knockout strains [Cadherin 5-cre/ERT2, floxed hemoglobin-α1 (Hba1

Indexed as

Blood GlucoseHousing, AnimalAnimalsBedding and LinensCelluloseFastingFemaleGlycated HemoglobinMaleMiceMice, Inbred C57BLReproducibility of ResultsBlood GlucoseCelluloseGlycated HemoglobinARRIVEblood glucosecorncob beddingmouse husbandryvascular function

Identifiers

PMID37389954
PMCPMC10435074

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.