Evidence map›Paper›PMID 37391691›Full record

ArticleBMC pregnancy and childbirth2023

Association between maternal cholesterol level during pregnancy and placental weight and birthweight ratio: data from the Japan Environment and Children's Study.

Naomi Mitsuda, Masamitsu Eitoku, Keiko Yamasaki, Naw Awn J-P, Mikiya Fujieda, Nagamasa Maeda, Narufumi Suganuma, Japan Environment and Children’s Study (JECS) Group

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Article in BMC pregnancy and childbirth, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Small Dense Low-Density Lipoprotein (sdLDL) and Its Correlates among Pregnant Women in Juth.Nigerian medical journal : journal of the Nigeria Medical Association
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Naomi MitsudaDepartment of Environmental Medicine, Kochi Medical School, Kochi University, Kochi, Japan. jm-nmitsuda@kochi-u.ac.jp.
Masamitsu EitokuDepartment of Environmental Medicine, Kochi Medical School, Kochi University, Kochi, Japan.
Keiko YamasakiDepartment of Environmental Medicine, Kochi Medical School, Kochi University, Kochi, Japan.
Naw Awn J-PDepartment of Environmental Medicine, Kochi Medical School, Kochi University, Kochi, Japan.
Mikiya FujiedaDepartment of Pediatrics, Kochi Medical School, Kochi University, Kochi, Japan.
Nagamasa MaedaDepartment of Obstetrics and Gynecology, Kochi Medical School, Kochi University, Kochi, Japan.
Narufumi SuganumaDepartment of Environmental Medicine, Kochi Medical School, Kochi University, Kochi, Japan.
Japan Environment and Children’s Study (JECS) Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPlacental weight to birthweight ratio (PW/BW ratio), or its inverse, is used as an indicator of placental efficiency. Past studies have shown an association between an abnormal PW/BW ratio and adverse intrauterine environment, however, no previous studies have examined the effect of abnormal lipid levels during pregnancy on PW/BW ratio. We aimed to evaluate the association between maternal cholesterol levels during pregnancy and placental weight to birthweight ratio (PW/BW ratio).

methodsThis study was a secondary analysis using the data from the Japan Environment and Children's Study (JECS). 81 781 singletons and their mothers were included in the analysis. Maternal serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels during pregnancy were obtained from participants. Associations between maternal lipid levels and placental weight and PW/BW ratio were assessed by regression analysis using restricted cubic splines.

resultsDose-response relationships were observed between maternal lipid level during pregnancy and placental weight and PW/BW ratio. High TC and LDL-C levels were associated with heavy placental weight and high PW/BW ratio, i.e., inappropriately heavy placenta for birthweight. Low HDL-C level was also associated with inappropriately heavy placenta. Low TC and LDL-C levels were associated with low placental weight and low PW/BW ratio, i.e., inappropriately light placenta for birthweight. High HDL-C was not associated with PW/BW ratio. These findings were independent of pre-pregnancy body mass index and gestational weight gain.

conclusionsAbnormal lipid levels such as elevated TC and LDL-C, and low HDL-C level, during pregnancy were associated with inappropriately heavy placental weight.

Indexed as

MothersPlacentaBirth WeightChildCholesterol, LDLFemaleHumansJapanPregnancyCholesterol, LDLBirthweightHypercholesterolemiaJapan Environment and Children’s StudyJECSPlacental efficiencyPlacental weightPregnancy

Identifiers

PMID37391691
PMCPMC10311780

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.