Evidence map›Paper›PMID 37395013›Full record

ArticleJournal of diabetes investigation2023

Urinary epidermal growth factor levels correlate with cardiovascular autonomic neuropathy indices in adults with type 1 diabetes.

Yu Kuei Lin, Emily Tanner, Yuee Wang, Wen Ye, Lynn Ang, Wenjun Ju, Rodica Pop-Busui

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes investigation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yu Kuei LinDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0003-1988-7046
Emily TannerDivision of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Yuee WangDivision of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Wen YeDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Lynn AngDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Wenjun JuDivision of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Rodica Pop-BusuiDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
University of Michigan · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Scott Soleimanpour · 2013 to 2026
$24.3M
Research BaseP30DK092926 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARY ELLEN MICHELE HEISLER, ADESUWA B OLOMU · 2011 to 2026
$10.0M
NIDDK Diabetic Foot Consortium Clinical Research UnitU01DK119083 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RODICA BUSUI (POP-BUSUI), Crystal Murray Holmes · 2018 to 2026
$5.5M
Targeting Inflammation with Salsalate as a Novel Therapy for Diabetic NeuropathyR01DK107956 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BUSUI (POP-BUSUI), RODICA, FELDMAN, EVA LUCILLE · 2016 to 2020
$3.0M
UroEDIC Bladder: Bladder Dysfunction in Type 1 DiabetesR01DK116723 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SARMA, ARUNA V, WESSELLS, HUNTER · 2021 to 2024
$2.5M
Minimizing Hypoglycemia in Adults with Type 1 Diabetes through an Integrated Mobile Health and Continuous Glucose Monitoring SystemK23DK129724 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIN, YU KUEI · 2021 to 2025
$984k
NIDDK NIH HHS K23 DK129724NIDDK NIH HHS K23DK129724NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK092926NIDDK NIH HHS R01 DK107956NIDDK NIH HHS R01DK107956NIDDK NIH HHS R01 DK116723NIDDK NIH HHS R01DK116723NIDDK NIH HHS U01 DK119083NIDDK NIH HHS U01DK119083
6 · The paper itself

Abstract

The relationship between urinary endothelial growth factor (uEGF) and cardiovascular autonomic neuropathy (CAN) in adults with type 1 diabetes was evaluated. uEGF levels at baseline and standardized CAN measures were collected at baseline and annually for 3 years for type 1 diabetes adults. Linear regression analysis and linear mixed effects model were used for analysis. In this cohort (n = 44, 59% women, mean ± standard deviation age 34 ± 13 years and diabetes duration 14 ± 6 years), lower baseline uEGF levels correlated with lower baseline expiration : inspiration ratios (P = 0.03) and greater annual declines in Valsalva ratios (P = 0.02) in the unadjusted model, and correlated with lower low-frequency power : high-frequency power ratios (P = 0.01) and greater annual changes in low-frequency power : high-frequency power ratios (P = 0.01) after adjustment for age, sex, body mass index, and hemoglobin A1C. In conclusion, baseline uEGF levels correlate to baseline and longitudinal changes in CAN indices. A large-scale, long-term study is needed to validate uEGF as a reliable CAN biomarker.

Indexed as

Autonomic Nervous System DiseasesDiabetes Mellitus, Type 1Diabetic NeuropathiesAdultAutonomic Nervous SystemBiomarkersEpidermal Growth FactorFemaleHumansMaleMiddle AgedYoung AdultBiomarkersEpidermal Growth FactorCardiovascular autonomic neuropathyEndothelial growth factorType 1 diabetes

Identifiers

PMID37395013
PMCPMC10512902
OpenAlexW4382919063

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.