Evidence map›Paper›PMID 37395873›Full record

ReviewCurrent neurology and neuroscience reports2023

Neuroinflammation in Acute Ischemic and Hemorrhagic Stroke.

Diana L Alsbrook, Mario Di Napoli, Kunal Bhatia, José Biller, Sasan Andalib, Archana Hinduja, Roysten Rodrigues, Miguel Rodriguez, Sara Y Sabbagh, Magdy Selim and 3 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current neurology and neuroscience reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 295 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
295citing papers in PubMed, 5 pooled it
48.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

295 citing papers in PubMed, 5 syntheses or guidelines pooled it, 397 citations in OpenAlex.

  1. Pooled it
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  4. Inflammatory cytokines are associated with stroke and risk factors of cerebrovascular diseases: a Mendelian randomization study.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
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  13. Platelet subpopulations and contribution to hemostasis.Blood science (Baltimore, Md.) · 2026
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235 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 3 countries.

Diana L AlsbrookDepartment of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA.
Mario Di NapoliNeurological Service, SS Annunziata Hospital, Sulmona, L'Aquila, Italy.
Kunal BhatiaDepartment of Neurology, University of Mississippi Medical Center, Jackson, MS, USA.
José BillerDepartment of Neurology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, USA.
Sasan AndalibResearch Unit of Neurology, Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
Archana HindujaDepartment of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Roysten RodriguesDepartment of Neurology, University of Louisville, Louisville, KY, USA.
Miguel RodriguezCollege of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Sara Y SabbaghDepartment of Neurology, University of New Mexico, Albuquerque, NM, USA.
Magdy SelimStroke Division, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Maryam Hosseini FarahabadiDepartment of Neurology, University of New Mexico, Albuquerque, NM, USA.
Alibay JafarliDepartment of Neurology, Tufts Medical Center, Boston, MA, USA.
Afshin A DivaniDepartment of Neurology, University of New Mexico, Albuquerque, NM, USA. adivani@gmail.com.
University of New Mexico · USUniversity of Tennessee Health Science Center · USHarvard University · USLoyola University Chicago · USOspedale SS. Annunziata · ITThe Ohio State University Wexner Medical Center · USTufts Medical Center · USUniversity of Louisville · USUniversity of Mississippi Medical Center · USUniversity of Southern Denmark · DK

Funding

Noninvasive Vagus Nerve Stimulation for Treatment of Brain Injury (nVNS-TBI) in RatsR21NS130423 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI DIVANI, AFSHIN ANDRE · 2022 to 2022
$419k
NINDS NIH HHS R21 NS130423
6 · The paper itself

Abstract

purpose of reviewThis review aims to provide an overview of neuroinflammation in ischemic and hemorrhagic stroke, including recent findings on the mechanisms and cellular players involved in the inflammatory response to brain injury. RECENT

findingsNeuroinflammation is a crucial process following acute ischemic stroke (AIS) and hemorrhagic stroke (HS). In AIS, neuroinflammation is initiated within minutes of the ischemia onset and continues for several days. In HS, neuroinflammation is initiated by blood byproducts in the subarachnoid space and/or brain parenchyma. In both cases, neuroinflammation is characterized by the activation of resident immune cells, such as microglia and astrocytes, and infiltration of peripheral immune cells, leading to the release of pro-inflammatory cytokines, chemokines, and reactive oxygen species. These inflammatory mediators contribute to blood-brain barrier disruption, neuronal damage, and cerebral edema, promoting neuronal apoptosis and impairing neuroplasticity, ultimately exacerbating the neurologic deficit. However, neuroinflammation can also have beneficial effects by clearing cellular debris and promoting tissue repair. The role of neuroinflammation in AIS and ICH is complex and multifaceted, and further research is necessary to develop effective therapies that target this process. Intracerebral hemorrhage (ICH) will be the HS subtype addressed in this review. Neuroinflammation is a significant contributor to brain tissue damage following AIS and HS. Understanding the mechanisms and cellular players involved in neuroinflammation is essential for developing effective therapies to reduce secondary injury and improve stroke outcomes. Recent findings have provided new insights into the pathophysiology of neuroinflammation, highlighting the potential for targeting specific cytokines, chemokines, and glial cells as therapeutic strategies.

Indexed as

Brain InjuriesHemorrhagic StrokeIschemic StrokeStrokeCerebral HemorrhageCytokinesHumansIschemiaNeuroinflammatory DiseasesCytokinesAstrocytesBrain damageChemokinesCytokinesEdemaGlial cellsHemorrhagic strokeImmune cellsInflammatory responseIntracerebral hemorrhageIschemic strokeMicrogliaNeuroinflammationPathophysiologySecondary injuryTherapeutic targets

Identifiers

PMID37395873
PMCPMC10544736
OpenAlexW4382918478

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.