Evidence map›Paper›PMID 37396167›Full record

ArticleFrontiers in endocrinology2023

Impact of an

George Firth, Eleni Georgiadou, Alexander Griffiths, Maral Amrahli, Jana Kim, Zilin Yu, Ming Hu, Theodora J Stewart, Isabelle Leclerc, Haruka Okamoto and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. A loss of function variant inmedRxiv : the preprint server for health sciences · 2026
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 4 countries.

George FirthSchool of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, United Kingdom.
Eleni GeorgiadouSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London, United Kingdom.
Alexander GriffithsLondon Metallomics Facility, King's College London, London, United Kingdom.
Maral AmrahliLondon Metallomics Facility, King's College London, London, United Kingdom.
Jana KimSchool of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, United Kingdom.
Zilin YuSchool of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, United Kingdom.
Ming HuSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London, United Kingdom.
Theodora J StewartLondon Metallomics Facility, King's College London, London, United Kingdom.
Isabelle LeclercSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London, United Kingdom.
Haruka OkamotoRegeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.
Daniel GomezRegeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.
Philip J BlowerSchool of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, United Kingdom.
Guy A RutterSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London, United Kingdom.
King's College London · GBCentre Hospitalier de l’Université de Montréal · CAImperial College London · GBRegeneron (United States) · USSt Thomas' Hospital · GBLondon Metropolitan University · GB

Funding

Medical Research Council MR/J0003042/1Medical Research Council MR/L020149/1Medical Research Council MR/N00275X/1Medical Research Council MR/S025618/1Wellcome TrustWellcome Trust 203148/Z/16/ZWellcome Trust 212885/Z/18/ZWellcome Trust WT098424AIA
6 · The paper itself

Abstract

Introduction: Common variants in the Methods: Following intravenous administration of [ Results: Our findings reveal that whereas uptake into organs, assessed using PET imaging of Discussion: These data challenge the view that zinc depletion from the beta cell is the likely underlying driver for protection from type 2 diabetes development in carriers of LoF alleles. Instead, they suggest that heterozygous LoF may paradoxically increase pancreatic β-cell zinc and manganese content and impact the levels of these metals in the exocrine pancreas to improve insulin secretion.

Indexed as

Cation Transport ProteinsDiabetes Mellitus, Type 2AnimalsHumansManganeseMicePancreasPancreatic HormonesPositron-Emission TomographyZincZinc Transporter 8Cation Transport ProteinsManganesePancreatic HormonesSLC30A8 protein, humanSlc30a8 protein, mouseZincZinc Transporter 8diabetesLA-ICP-MSmanganesepancreaspositron emission tomographySLC30A8zinc

Identifiers

PMID37396167
PMCPMC10313231
OpenAlexW4380987902

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.