Evidence map›Paper›PMID 37396516›Full record

ArticleGenes & diseases2023

The miR-21-5p enriched in the apoptotic bodies of M2 macrophage-derived extracellular vesicles alleviates osteoarthritis by changing macrophage phenotype.

Leilei Qin, Jianye Yang, Xudong Su, Xilan Li, Yiting Lei, Lili Dong, Hong Chen, Cheng Chen, Chen Zhao, Huan Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Article
  2. Apoptotic Bodies in Kidney Disease: Orchestrators of Inflammation, Fibrosis, and Repair.Journal of the American Society of Nephrology : JASN · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. From pathogenesis to therapy: extracellular vesicles in osteoarthritis.Frontiers in bioengineering and biotechnology · 2026
    Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Leilei QinDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Jianye YangDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Xudong SuDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Xilan LiInstitute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Army Medical University, Chongqing 400038, China.
Yiting LeiDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Lili DongDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Hong ChenDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Cheng ChenDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Chen ZhaoDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Huan ZhangDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Jun DengInstitute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Army Medical University, Chongqing 400038, China.
Ning HuDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Wei HuangDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophages (Mφs) play a crucial role in the pathological progression of osteoarthritis (OA) by regulating inflammation and tissue repair. Decreasing pro-inflammatory M1-Mφs and increasing anti-inflammatory M2-Mφs can alleviate OA-related inflammation and promote cartilage repair. Apoptosis is a natural process associated with tissue repair. A large number of apoptotic bodies (ABs), a type of extracellular vesicle, are produced during apoptosis, and this is associated with a reduction in inflammation. However, the functions of apoptotic bodies remain largely unknown. In this study, we investigated the role of M2-Mφs-derived apoptotic bodies (M2-ABs) in regulating the M1/M2 balance of macrophages in a mouse model of OA. Our data show that M2-ABs can be targeted for uptake by M1-Mφs, and this reprograms M1-to-M2 phenotypes within 24 h. The M2-ABs significantly ameliorated the severity of OA, alleviated the M1-mediated pro-inflammatory environment, and inhibited chondrocyte apoptosis in mice. RNA-seq revealed that M2-ABs were enriched with miR-21-5p, a microRNA that is negatively correlated with articular cartilage degeneration. Inhibiting the function of miR-21-5p in M1-Mφs significantly reduced M2-ABs-guided M1-to-M2 reprogramming following

Indexed as

Apoptotic bodyExtracellular vesiclesMacrophage phenotype switchMicroRNA-21Osteoarthritis

Identifiers

PMID37396516
PMCPMC10308169

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.