Evidence map›Paper›PMID 37397246›Full record

ArticleFrontiers in cell and developmental biology2023

Promising AAV.U7snRNAs vectors targeting

Camila F Almeida, Florence Robriquet, Tatyana A Vetter, Nianyuan Huang, Reid Neinast, Lumariz Hernandez-Rosario, Dhanarajan Rajakumar, W David Arnold, Kim L McBride, Kevin M Flanigan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. RNA-Based Therapeutic Technology.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Camila F AlmeidaCenter for Gene Therapy, Nationwide Children's Hospital, Columbus, OH, United States.
Florence RobriquetCenter for Gene Therapy, Nationwide Children's Hospital, Columbus, OH, United States.
Tatyana A VetterCenter for Gene Therapy, Nationwide Children's Hospital, Columbus, OH, United States.
Nianyuan HuangCenter for Gene Therapy, Nationwide Children's Hospital, Columbus, OH, United States.
Reid NeinastCenter for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH, United States.
Lumariz Hernandez-RosarioCenter for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH, United States.
Dhanarajan RajakumarCenter for Gene Therapy, Nationwide Children's Hospital, Columbus, OH, United States.
W David ArnoldDepartment of Neurology, The Ohio State University, Columbus, OH, United States.
Kim L McBrideCenter for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH, United States.
Kevin M FlaniganCenter for Gene Therapy, Nationwide Children's Hospital, Columbus, OH, United States.
Robert B WeissDepartment of Human Genetics, The University of Utah School of Medicine, Salt Lake City, UT, United States.
Nicolas WeinCenter for Gene Therapy, Nationwide Children's Hospital, Columbus, OH, United States.

Funding

Project 3: Use of an IRES-driven N-truncated dystrophin isoform as a clinical therapy for 5 mutations in the dystrophinopathiesP50AR070604 · NIAMS · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI FLANIGAN, KEVIN M · 2016 to 2020
$7.3M
NIAMS NIH HHS P50 AR070604
6 · The paper itself

Abstract

Myotonic dystrophy type 1 (DM1) is the most common form of muscular dystrophy in adults and affects mainly the skeletal muscle, heart, and brain. DM1 is caused by a CTG repeat expansion in the 3'UTR region of the

Indexed as

aavgene therapymyotonic dystrophyspliceopathyU7snRNA

Identifiers

PMID37397246
PMCPMC10309041

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.