ArticleFrontiers in public health2023
Causal relationship between obesity and iron deficiency anemia: a two-sample Mendelian randomization study.
Article in Frontiers in public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Causal relationship between autoimmune diseases and iron deficiency anemia: a two-sample mendelian randomization study.Scientific reports · 2026Article
- Prevalence and determinants of anaemia among university students: a gender-based analysis.Frontiers in public health · 2026Article
- Prevalence of iron deficiency in patients with mild to moderate bleeding disorders and bleeding disorder of unknown cause.Research and practice in thrombosis and haemostasis · 2025Article
- Outcomes of elective repair of large hiatus hernias in the morbidly obese: a cohort study.Surgical endoscopy · 2025Article
- Impact of Side Effects on Anemia Therapy Compliance.Nutrients · 2025Observational
- Breast Cancer and Meningioma Risk: A Mendelian Randomization Study.Brain and behavior · 2025Article
- Association of life's essential 8 and inflammatory biomarkers with nutritional anemia in UK adults.Scientific reports · 2025Article
- Exploring the role of nutritional status and anthropometric factors in anemia among adolescent girls in Pekanbaru, Indonesia.SAGE open medicine · 2025Article
- The Prevalence and Characteristics of Anemia in Romanian Patients with Type 2 Diabetes: A Cross-Sectional Study.Journal of clinical medicine · 2024Article
- Association between Adiposity and Iron Status in Women of Reproductive Age: Data from the UK National Diet and Nutrition Survey (NDNS) 2008-2019.The Journal of nutrition · 2024Article
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Corrections and comments
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Observational studies have suggested an association between obesity and iron deficiency anemia, but such studies are susceptible to reverse causation and residual confounding. Here we used Mendelian randomization to assess whether the association might be causal. Methods: Data on single-nucleotide polymorphisms that might be associated with various anthropometric indicators of obesity were extracted as instrumental variables from genome-wide association studies in the UK Biobank. Data on genetic variants in iron deficiency anemia were extracted from a genome-wide association study dataset within the Biobank. Heterogeneity in the data was assessed using inverse variance-weighted regression, Mendelian randomization Egger regression, and Cochran's Q statistic. Potential causality was assessed using inverse variance-weighted, Mendelian randomization Egger, weighted median, maximum likelihood and penalized weighted median methods. Outlier SNPs were identified using Mendelian randomization PRESSO analysis and "leave-one-out" analysis. Results: Inverse variance-weighted regression associated iron deficiency anemia with body mass index, waist circumference, trunk fat mass, body fat mass, trunk fat percentage, and body fat percentage (all odds ratios 1.003-1.004, Conclusion: Our Mendelian randomization analysis suggests that obesity can cause iron deficiency anemia.
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