Evidence map›Paper›PMID 37397986›Full record

ArticlebioRxiv : the preprint server for biology2023

Secondary structures that regulate mRNA translation provide insights for ASO-mediated modulation of cardiac hypertrophy.

Omar M Hedaya, Kadiam C Venkata Subbaiah, Feng Jiang, Li Huitong Xie, Jiangbin Wu, EngSoon Khor, Mingyi Zhu, David H Mathews, Chris Proschel, Peng Yao

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Omar M HedayaAab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine & Dentistry, Rochester, New York 14642.
Kadiam C Venkata SubbaiahAab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine & Dentistry, Rochester, New York 14642.
Feng JiangAab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine & Dentistry, Rochester, New York 14642.
Li Huitong XieDepartment of Biomedical Genetics, University of Rochester School of Medicine & Dentistry, Rochester, New York 14642.
Jiangbin WuAab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine & Dentistry, Rochester, New York 14642.
EngSoon KhorAab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine & Dentistry, Rochester, New York 14642.
Mingyi ZhuDepartment of Biochemistry & Biophysics, University of Rochester School of Medicine & Dentistry, Rochester, New York 14642.
David H MathewsDepartment of Biochemistry & Biophysics, University of Rochester School of Medicine & Dentistry, Rochester, New York 14642.
Chris ProschelDepartment of Biomedical Genetics, University of Rochester School of Medicine & Dentistry, Rochester, New York 14642.
Peng YaoAab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine & Dentistry, Rochester, New York 14642.
University of Rochester · US

Funding

Training in Cellular, Biochemical and Molecular SciencesT32GM068411 · NIGMS · UNIVERSITY OF ROCHESTER · PI MAQUAT, LYNNE E · 2005 to 2019
$3.9M
RNA Structure Modeling Using Physics and Sequence ComparisonR35GM145283 · NIGMS · UNIVERSITY OF ROCHESTER · PI DAVID H. MATHEWS · 2022 to 2026
$2.7M
uORF-mediated Translational Control of Cardiac Transcription Factor ExpressionR01HL164584 · NHLBI · UNIVERSITY OF ROCHESTER · PI Peng Yao · 2023 to 2026
$2.0M
Deciphering the role of FAM210A in cardiac physiopathologyR01HL169432 · NHLBI · UNIVERSITY OF ROCHESTER · PI Peng Yao · 2023 to 2026
$1.9M
Translational Control of Cardiac FibrosisR01HL147954 · NHLBI · UNIVERSITY OF ROCHESTER · PI YAO, PENG · 2019 to 2022
$1.5M
Role of miR-574-Fam210a axis in cardiac hypertrophy and remodelingR01HL132899 · NHLBI · UNIVERSITY OF ROCHESTER · PI YAO, PENG · 2018 to 2021
$1.5M
Automated Comparative Sequence Analysis of RNA Secondary and Tertiary StructureR01GM132185 · NIGMS · UNIVERSITY OF ROCHESTER · PI MATHEWS, DAVID H. · 2019 to 2022
$1.2M
iPSC-derived astrocytes to model Vanishing White Matter DiseaseR21NS104878 · NINDS · UNIVERSITY OF ROCHESTER · PI PROSCHEL, CHRISTOPH · 2018 to 2019
$452k
NHLBI NIH HHS R01 HL132899NHLBI NIH HHS R01 HL147954NHLBI NIH HHS R01 HL164584NHLBI NIH HHS R01 HL169432NIGMS NIH HHS R01 GM132185NIGMS NIH HHS R35 GM145283NIGMS NIH HHS T32 GM068411NINDS NIH HHS R21 NS104878
6 · The paper itself

Abstract

Translation of upstream open reading frames (uORFs) typically abrogates translation of main (m)ORFs. The molecular mechanism of uORF regulation in cells is not well understood. Here, we identified a double-stranded RNA (dsRNA) structure residing within the Bullet points for discoveries: dsRNA within

Identifiers

PMID37397986
PMCPMC10312771
OpenAlexW4380879200

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.