ArticleResearch square2023
Obesity-dependent increase in RalA activity disrupts mitochondrial dynamics in white adipocytes.
Wenmin Xia, Preethi Veeragandham, Yu Cao, Yayun Xu, Torrey Rhyne, Jiaxin Qian, Chao-Wei Hung, Peng Zhao, Ying Jones, Hui Gao and 9 more
Open access · greenAbstract readPreprint
In one paragraphArticle in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
19 authors at 7 institutions in 3 countries.
Preethi VeeragandhamUniversity of California San Diego.
Yu CaoUniversity of California San Diego.
Yayun XuUniversity of California San Diego.
Torrey RhyneUniversity of California San Diego.
Jiaxin QianUniversity of California San Diego.
Chao-Wei HungUniversity of North Carolina.
Ying JonesUniversity of California San Diego.
Christopher LiddleSalk Institute for Biological Studies.
Michael DownesSalk Institute.
Shannon ReillyWeill Medical College of Cornell University.
Jianfeng HuangSalk Institute for Biological Studies.
University of California San Diego · USSalk Institute for Biological Studies · USKarolinska Institutet · SECornell University · USThe University of Texas Health Science Center at San Antonio · USUniversidad Católica Santo Domingo · DOUniversity Medical Center · US
Funding
VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4MRegulating energy expenditure in adipose tissueR01DK124496 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SALTIEL, ALAN R. · 2020 to 2024
$2.7MHormonal Regulation of Mammalian Gene ExpressionR01DK057978 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2021 to 2024
$2.6MAdipose tissue plasticity in health and diseaseR01DK122804 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SALTIEL, ALAN R., WEISS, STEPHEN J · 2020 to 2023
$2.4MInflammation and hepatic lipid metabolismR01DK125820 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SALTIEL, ALAN R. · 2020 to 2023
$2.1MRegulation of fatty acid metabolism in adipocytesR01DK126944 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI REILLY, SHANNON MARIE · 2021 to 2025
$2.1MHormonal regulation of LDL receptor traffickingR01DK128796 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SALTIEL, ALAN R. · 2021 to 2024
$1.8MProtective effects of amlexanox against atherosclerosisR00HL143277 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ZHAO, PENG · 2021 to 2023
$747kJEOL JEM-1400Plus Transmission Electron MicroscopeS10OD023527 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FARQUHAR, MARILYN GIST · 2017 to 2017
$579kNCI NIH HHS P30 CA023100NHLBI NIH HHS R00 HL143277NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK057978NIDDK NIH HHS R01 DK122804NIDDK NIH HHS R01 DK124496NIDDK NIH HHS R01 DK125820NIDDK NIH HHS R01 DK126944NIDDK NIH HHS R01 DK128796NIH HHS S10 OD023527
6 · The paper itselfAbstract
Mitochondrial dysfunction is a characteristic trait of human and rodent obesity, insulin resistance, and fatty liver disease. Here we report that mitochondria undergo fragmentation and reduced oxidative capacity specifically in inguinal white adipose tissue after feeding mice high fat diet (HFD) by a process dependent on the small GTPase RalA. RalA expression and activity are increased in white adipocytes from mice fed HFD. Targeted deletion of
Identifiers
PMID37398165
PMCPMC10312969
OpenAlexW4379113857
What Socratic holds
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