ArticleResearch square2023
QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration.
Jayshree Advani, Ximena Corso-Diaz, Madeline Kwicklis, Freekje van Asten, Rinki Ratnapriya, Puja Mehta, Andrew Hamel, Sudeep Mahrotra, Ayellet Segrè, Christina Kiel and 7 more
Open access · greenAbstract readPreprint
In one paragraphArticle in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 5 citations in OpenAlex.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
17 authors at 5 institutions in 2 countries.
Jayshree AdvaniNational Eye Institute, National Institutes of Health.
Ximena Corso-DiazNational Eye Institute.
Madeline KwicklisNational Eye Institute, National Institutes of Health.
Freekje van AstenNational Eye Institute, National Institutes of Health.
Rinki RatnapriyaNational Eye Institute, National Institutes of Health.
Puja MehtaDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3205-1163 Sudeep MahrotraMass Eye and Ear, Harvard Med Sch.
Ayellet SegrèMassachusetts Eye and Ear.
Christina KielUniversity of Regensburg.
Tobias StrunzUniversity of Regensburg.
Dena HernandezNational Institutes of Health.
Sandra MontezumaUniversity of Minnesota.
Deborah FerringtonUniversity of Minnesota.
National Institutes of Health · USBroad Institute · USUniversity of Minnesota · USUniversity of Regensburg · DEUniversity Hospital Regensburg · DE
Funding
Regulation of retinal developmentZIAEY000450 · NEI · NATIONAL EYE INSTITUTE · PI SWAROOP, ANAND · 2009 to 2025
$71.0MMechanisms, modeling and therapies of retinal and macular neurodegenerationZIAEY000546 · NEI · NATIONAL EYE INSTITUTE · PI SWAROOP, ANAND · 2015 to 2025
$36.3MP30 Core Grant for Vision ResearchP30EY014104 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Janey L Wiggs · 2002 to 2026
$15.1MUncovering novel biological processes and pathogenic mechanisms for glaucomaR01EY031424 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Ayellet Vered Segre · 2020 to 2026
$4.5MIntramural NIH HHS ZIA EY000450Intramural NIH HHS ZIA EY000546NEI NIH HHS P30 EY014104NEI NIH HHS R01 EY031424
6 · The paper itselfAbstract
DNA methylation (DNAm) provides a crucial epigenetic mark linking genetic variations to environmental influence. We analyzed array-based DNAm profiles of 160 human retinas with co-measured RNA-seq and > 8 million genetic variants, uncovering sites of genetic regulation in
Indexed as
agingepigenomeeQTLeQTMgene expressionGWASmQTLneurodegenerationretina
Identifiers
PMID37398472
PMCPMC10312909
OpenAlexW4380875448
What Socratic holds
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LicenceCC BY
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