ArticlemedRxiv : the preprint server for health sciences2023
The MIND diet, brain transcriptomic alterations, and dementia.
Jun Li, Ana W Capuano, Puja Agarwal, Zoe Arvanitakis, Yanling Wang, Philip L De Jager, Julie A Schneider, Shinya Tasaki, Katia de Paiva Lopes, Frank B Hu and 3 more
Open access · greenAbstract readPreprint
In one paragraphArticle in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
13 authors at 3 institutions in 1 country.
Jun LiDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School.
Ana W CapuanoRush Alzheimer's Disease Center, Rush University Medical Center.
Puja AgarwalRush Alzheimer's Disease Center, Rush University Medical Center.
Zoe ArvanitakisRush Alzheimer's Disease Center, Rush University Medical Center.
Yanling WangRush Alzheimer's Disease Center, Rush University Medical Center.
Philip L De JagerCenter for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center.
Julie A SchneiderRush Alzheimer's Disease Center, Rush University Medical Center.
Shinya TasakiRush Alzheimer's Disease Center, Rush University Medical Center.
Katia de Paiva LopesRush Alzheimer's Disease Center, Rush University Medical Center.
Frank B HuDepartment of Nutrition, Harvard T.H. Chan School of Public Health.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center.
Liming LiangDepartment of Epidemiology, Harvard T.H. Chan School of Public Health.
Francine GrodsteinRush Alzheimer's Disease Center, Rush University Medical Center.
Rush University Medical Center · USBrigham and Women's Hospital · USHarvard University · US
Funding
SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MMulti-omic network-directed proteoform discovery, dissection and functional validation to prioritize novel AD therapeutic targetsU01AG061356 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2018 to 2022
$13.7MLinking peripheral and brain insulin resistance to AD neuropathology and cognitionRF1AG059621 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI AHIMA, REXFORD S., ARNOLD, STEVEN E · 2018 to 2018
$3.8MThe role of blood and brain 5-hydroxymethylcytosine in linking vascular risk factors to ADRD in older White and Black personsRF1AG074549 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI ARVANITAKIS, ZOE · 2021 to 2021
$3.3MMechanisms linking insulin resistance to brain structure, pathology, and functionR01NS084965 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI AHIMA, REXFORD S., ARNOLD, STEVEN E · 2014 to 2018
$3.2MDiet Patterns and Alzheimer Disease and Other DementiasR01AG054476 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI SCHNEIDER, JULIE A. · 2017 to 2021
$2.3MChronic Inflammation and Type 2 Diabetes: A Multi-omics ApproachR00DK122128 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI LI, JUN · 2022 to 2024
$723kNIA NIH HHS P30 AG010161NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG054476NIA NIH HHS RF1 AG059621NIA NIH HHS RF1 AG074549NIA NIH HHS U01 AG061356NIDDK NIH HHS R00 DK122128NINDS NIH HHS R01 NS084965
6 · The paper itselfAbstract
Identifying novel mechanisms underlying dementia is critical to improving prevention and treatment. As an approach to mechanistic discovery, we investigated whether MIND diet (Mediterranean-DASH Diet Intervention for Neurodegenerative Delay), a consistent risk factor for dementia, is correlated with a specific profile of cortical gene expression, and whether such a transcriptomic profile is associated with dementia, in the Religious Orders Study (ROS) and Rush Memory and Aging Project (MAP). RNA sequencing (RNA-Seq) was conducted in postmortem dorsolateral prefrontal cortex tissue from 1,204 deceased participants; neuropsychological assessments were performed annually prior to death. In a subset of 482 participants, diet was assessed ~6 years before death using a validated food-frequency questionnaire; in these participants, using elastic net regression, we identified a transcriptomic profile, consisting of 50 genes, significantly correlated with MIND diet score (
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PMID37398494
PMCPMC10312892
OpenAlexW4380449863
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