Evidence map›Paper›PMID 37399333›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Dynorphinergic Projections from the Central Amygdala to the Parabrachial Nucleus Regulate Itch.

Hideki Funahashi, Darya Pavlenko, Kent Sakai, Rebecca Verpile, Kristen M Sanders, Tasuku Akiyama

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Supraspinal Circuit Mechanisms Underlying Itch Processing.CNS neuroscience & therapeutics · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Distinct eLPBTheranostics · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Hideki FunahashiDr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center, University of Miami Miller School of Medicine, Miami, FL 33136.
Darya PavlenkoDr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center, University of Miami Miller School of Medicine, Miami, FL 33136.
Kent SakaiDr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center, University of Miami Miller School of Medicine, Miami, FL 33136.
Rebecca VerpileDr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center, University of Miami Miller School of Medicine, Miami, FL 33136.
Kristen M SandersDr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center, University of Miami Miller School of Medicine, Miami, FL 33136.
Tasuku AkiyamaDr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center, University of Miami Miller School of Medicine, Miami, FL 33136 takiyama@miami.edu.ORCID 0000-0001-7155-4228
University of Miami · USUniversity of Miyazaki · JP

Funding

The neuronal circuits of affective itchR01AR074062 · NIAMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI AKIYAMA, TASUKU · 2018 to 2022
$1.7M
NIAMS NIH HHS R01 AR074062
6 · The paper itself

Abstract

The amygdala plays a key role in the processing of itch and pain signals as well as emotion. A previous study revealed that the central nucleus of the amygdala (CeA)-parabrachial nucleus (PBN) pathway is involved in pain regulation. The same pathway might also control itch. To test this possibility, prodynorphin (Pdyn)-Cre mice were used to optogenetically manipulate Pdyn

Indexed as

Central Amygdaloid NucleusParabrachial NucleusAnimalsChloroquineMiceNeuronsPainPruritusChloroquineamygdalaanxietyitchmicepainparabrachial nucleus

Identifiers

PMID37399333
PMCPMC10359027
OpenAlexW4382657176

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.