Evidence map›Paper›PMID 37401629›Full record

ArticleeLife2023

Extensive remodelling of the cell wall during the development of

Edward J A Douglas, Nathanael Palk, Tarcisio Brignoli, Dina Altwiley, Marcia Boura, Maisem Laabei, Mario Recker, Gordon Y C Cheung, Ryan Liu, Roger C Hsieh and 4 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Metabolic reprogramming promotesMicrobiology (Reading, England) · 2026
    Article
  4. Host-driven remodelling of theMicrobiology (Reading, England) · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Surviving in the blood.Nature reviews. Microbiology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 5 countries.

Edward J A Douglas *School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom.ORCID https://orcid.org/0000-0001-5892-8539
Nathanael Palk *School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom.ORCID https://orcid.org/0000-0002-6918-8852
Tarcisio BrignoliSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom.
Dina AltwileySchool of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom.
Marcia BouraSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom.
Maisem LaabeiDepartment of Life Sciences, University of Bath, Bath, United Kingdom.ORCID https://orcid.org/0000-0002-8425-3704
Mario ReckerInstitute of Tropical Medicine, University of Tübingen, Tübingen, Germany.ORCID https://orcid.org/0000-0001-9489-1315
Gordon Y C CheungLaboratory of Bacteriology, National Institute of Allergy and Infectious Diseases (NIAID), US National Institutes of Health (NIH), Bethesda, United States.
Ryan LiuLaboratory of Bacteriology, National Institute of Allergy and Infectious Diseases (NIAID), US National Institutes of Health (NIH), Bethesda, United States.
Roger C HsiehLaboratory of Bacteriology, National Institute of Allergy and Infectious Diseases (NIAID), US National Institutes of Health (NIH), Bethesda, United States.
Michael OttoLaboratory of Bacteriology, National Institute of Allergy and Infectious Diseases (NIAID), US National Institutes of Health (NIH), Bethesda, United States.
Eoin O'BrienHost Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland.
Rachel M McLoughlinHost Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland.
Ruth C MasseySchool of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom.ORCID https://orcid.org/0000-0002-8154-4039
National Institutes of Health · USUniversity of Bristol · GBTrinity College Dublin · IEUniversity College Cork · IEUniversity of Bath · GBUniversity of Exeter · GBUniversity of Milan · IT

Funding

Staphylococcal pathogenesisZIAAI000904 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI OTTO, MICHAEL · 2009 to 2025
$22.6M
Staphylococcus Epidermidis Biofilm FormationZ01AI000904 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI OTTO, MICHAEL J · 2002 to 2008
$2.5M
Biotechnology and Biological Sciences Research Council SWBio DTPIntramural NIH HHS Z01 AI000904Intramural NIH HHS ZIA AI000904Wellcome Trust 202846/Z/16/ZWellcome Trust 212258/Z/18/Z
6 · The paper itself

Abstract

The bloodstream represents a hostile environment that bacteria must overcome to cause bacteraemia. To understand how the major human pathogen

Indexed as

BacteremiaStaphylococcal InfectionsAnimalsAnti-Bacterial AgentsCell WallHumansMiceStaphylococcus aureusTeichoic AcidsAnti-Bacterial AgentsTeichoic Acidsbacteraemiainfectious diseasemicrobiologystaphylococcus aureusStaphylococcus aureusTcaA

Identifiers

PMID37401629
PMCPMC10328498
OpenAlexW4365514419

What Socratic holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.