ArticleNutrition & diabetes2023
The heterogeneous associations between gestational weight gain and adverse pregnancy outcomes in gestational diabetes mellitus according to abnormal glucose metabolism.
Article in Nutrition & diabetes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Interaction between triglyceride-glucose index and body mass index on pregnancy loss in Chinese women with polycystic ovary syndrome: a secondary analysis of a randomized clinical trial.Reproductive biology and endocrinology : RB&E · 2026Article
- Trimester-specific gestational weight gain and adverse outcomes in GDM women: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- GDM modified the associations of gestational weight gain with pregnancy outcomes: a population-based cohort study.Journal of translational medicine · 2025Article
- Metabolomics of saliva, serum, and urine for pathogenesis, diagnosis, and prognosis in gestational diabetes mellitus.Nature communications · 2025Article
- Dose-response association between OGTT and adverse perinatal outcomes after IVF treatment: A cohort study based on a twin population.Journal of endocrinological investigation · 2025Article
- The relative validity of a semiquantitative food frequency questionnaire among pregnant women in the United Arab Emirates: The Mutaba'ah study.Nutrition and health · 2025Article
- Medical Nutrition Therapy for Women with Gestational Diabetes: Current Practice and Future Perspectives.Nutrients · 2025Review
- Gestational weight trajectory and early offspring growth differed by gestational diabetes: a population-based cohort study.Nutrition & diabetes · 2025Article
- The role of lipid dysregulation in gestational diabetes mellitus: Early prediction and postpartum prognosis.Journal of diabetes investigation · 2024Review
- Gestational diabetes-combined excess weight gain exacerbates gut microbiota dysbiosis in newborns, associated with reduced abundance ofFrontiers in cellular and infection microbiology · 2024Article
- Improved pregnancy outcome in gestational diabetes mellitus patients treated with insulin aspart and metformin: a comparative study.American journal of translational research · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe gestational weight gain (GWG) and hyperglycemia are two key factors affecting adverse pregnancy outcomes among women with gestational diabetes mellitus (GDM). We aimed to investigate the combinatorial effect of abnormal glucose metabolism and GWG on adverse outcomes in GDM.
methodsThis retrospective cohort study included 2611 pregnant women with GDM in Women's Hospital School of Medicine Zhejiang University. Bases on the OGTT glucose levels, we categorized the GDM cohort into three subgroups: impaired fasting glucose (IFG) group, impaired glucose tolerance (IGT) group, and combined impaired glucose (IFG&IGT) group.
resultsAmong pregnant women with IGT, insufficient GWG (IGWG) was an independent protective factor for pregnancy-induced hypertension syndrome (PIH) (aOR 0.55, 95% CI 0.32-0.95), macrosomia (0.38, 0.19-0.74) and large for gestational age (0.45, 0.32-0.62), as well as an independent risk factor for low birth weight infants (2.29, 1.24-4.22) and small for gestational age (1.94, 1.17-3.19); and excessive GWG (EGWG) was related to increased risks of PIH (1.68, 1.12-2.52), preterm delivery (1.82, 1.28-2.58), postpartum hemorrhage (1.85, 1.05-3.28), cesarean delivery (1.84, 1.38-2.46) and low body weight infants (2.36, 1.33-4.20). Moreover, EGWG was positively associated with PIH (3.27, 1.09-9.80) in the IFG group. But there were no significant associations between either IGWG or EGWG and any pregnancy outcomes in women with combined IFG&IGT.
conclusionsThe relationships between GWG and adverse outcomes were modified by abnormal glucose metabolism in women with GDM. Our results suggest that more specific GWG recommendations according to their metabolic state are needed for GDM.
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