Evidence map›Paper›PMID 37403338›Full record

ArticleJournal of diabetes2023

Protective effects of nattokinase against microvasculopathy and neuroinflammation in diabetic retinopathy.

Zijing Huang, Wai Kit Chu, Tsz Kin Ng, Shaolang Chen, Jiajian Liang, Chong-Bo Chen, Yanxuan Xu, Biyao Xie, Shuping Ke, Qingping Liu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. [Quantitative Assessment of Microvascular Changes in Diabetic Retinopathy and Their Association With Blood-Retinal Barrier Impairment].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 2 countries.

Zijing HuangJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China.ORCID https://orcid.org/0000-0003-2909-2538
Wai Kit ChuDepartment of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Tsz Kin NgJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China.ORCID https://orcid.org/0000-0001-7863-7229
Shaolang ChenJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China.
Jiajian LiangJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China.
Chong-Bo ChenJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China.ORCID https://orcid.org/0000-0003-1421-4109
Yanxuan XuJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China.
Biyao XieJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China.
Shuping KeJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China.
Qingping LiuJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China.
Weiqi ChenJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China.
Dingguo HuangJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China.
Chinese University of Hong Kong · HK

Funding

National Natural Science Foundation of China 82101112Special Support Plan for High-Level Talents in Guangdong Province for Young Top Talents in Science and Technology Innovation N/A
6 · The paper itself

Abstract

aimsDiabetic retinopathy (DR) is a significant global public health concern. Alternative, safe, and cost-effective pharmacologic approaches are warranted. We aimed to investigate the therapeutic potential of nattokinase (NK) for early DR and the underlying molecular mechanism.

methodsA mouse model of diabetes induced by streptozotocin was utilized and NK was administered via intravitreal injection. Microvascular abnormities were evaluated by examining the leakage from blood-retinal barrier dysfunction and loss of pericytes. Retinal neuroinflammation was examined through the assessment of glial activation and leukostasis. The level of high mobility group box 1 (HMGB1) and its downstream signaling molecules was evaluated following NK treatment.

resultsNK administration significantly improved the blood-retinal barrier function and rescued pericyte loss in the diabetic retinas. Additionally, NK treatment inhibited diabetes-induced gliosis and inflammatory response and protected retinal neurons from diabetes-induced injury. NK also improved high glucose-induced dysfunction in cultured human retinal micrangium endothelial cells. Mechanistically, NK regulated diabetes-induced inflammation partially by modulating HMGB1 signaling in the activated microglia.

conclusionsThis study demonstrated the protective effects of NK against microvascular damages and neuroinflammation in the streptozotocin-induced DR model, suggesting that NK could be a potential pharmaceutical agent for the treatment of DR.

Indexed as

Diabetes Mellitus, ExperimentalDiabetic RetinopathyMicrovesselsNeuroinflammatory DiseasesSubtilisinsAnimalsBlood-Retinal BarrierEndothelial CellsHMGB1 ProteinHumansMaleMiceMice, Inbred C57BLSignal TransductionHMGB1 ProteinnattokinaseSubtilisinsdiabetic retinopathyhigh mobility group box 1microvasculopathynattokinaseneuroinflammation微血管病变神经炎症糖尿病视网膜病变纳豆激酶高迁移率族蛋白B1

Identifiers

PMID37403338
PMCPMC10590680
OpenAlexW4383187205

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.