ArticleJournal of dental sciences2023
The effect of kaempferol on the dentin bonding stability through matrix metalloproteinases inhibition and collagen crosslink in dentin biomodification.
Article in Journal of dental sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- The contribution of different types of polyphenols to bonding performance by enhancing the stabilization of the hybrid layer.Clinical oral investigations · 2026Article
- Transdentinal effects of flavonoid-based primers applied to caries-affected dentin on pulp cells.Clinical oral investigations · 2025Review
- Self-assembled silk fibroin as an interfacial reinforcer: A synergistic strategy with amorphous calcium phosphate for durable dentin bonding.Materials today. Bio · 2025Article
- Biomineralization of dental tissues with natural drugs: a comprehensive review.The Saudi dental journal · 2025Review
- Bond preservation in caries-affected dentin restored with acrylamide-based adhesives.Dental materials : official publication of the Academy of Dental Materials · 2025Article
- In vitro study of the treatment of dentin hypersensitivity with gallic acid combined with sodium fluoride.BMC oral health · 2024Article
- Pharmacological Potential of Kaempferol, a Flavonoid in the Management of Pathogenesis via Modulation of Inflammation and Other Biological Activities.Molecules (Basel, Switzerland) · 2024Review
- Polyphenols Can Improve Resin-Dentin Bond Durability by Promoting Amorphous Calcium Phosphate Nanoparticles to Backfill the Dentin Matrix.International journal of nanomedicine · 2023Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/purpose: Naturally derived collagen crosslinkers with matrix metalloproteinases (MMPs) inhibitory activity for dentin bonding have been previously studied. One of these crosslinkers is flavonoids. The purpose of this study was to investigate whether dentin pretreatment with kaempferol (KEM), one of the flavonoids, enhances dentin bond stability and nanoleakage at the dentin-resin interface through MMPs inhibition and collagen crosslinking. Materials and methods: The experimental KEM-containing solution was used to pretreat demineralized dentin prior to the application of a universal adhesive. KEM is a natural flavonoid and those which did not take the experimental solution served as the control group (CON). Microtensile bond strength (μTBS) and nanoleakage tests were conducted before and after the thermocycling to evaluate the influence of KEM on dentin bond strength. The MMPs inhibition activity of KEM was analyzed via MMPs zymography using a confocal microscopy. Fourier-transform infrared (FTIR) spectroscopy was used to demonstrate that KEM inhibits MMPs and enhances collagen crosslinking. Results: The μTBS values of KEM group exhibited a higher bond strength after thermocycling. At the resin-dentin interface, the KEM group did not exhibit any signs of nanoleakage after thermocycling. Furthermore, MMPs zymography confirmed that there was a relatively low activity of MMPs in the presence of KEM. In FTIR analysis, the PO Conclusion: Our findings suggest that pretreatment with KEM enhances the dentin bonding stability at the resin-dentin interface by acting as a collagen crosslinker and MMPs inhibitor.
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Registered trials
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