ArticleScience translational medicine2023
Dysregulated IFN-γ signals promote autoimmunity in STAT1 gain-of-function syndrome.
Abstract read
In one paragraph
Article in Science translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 27 citations in OpenAlex.
- JAK-inhibitor treatment induces rapid yet incomplete immune reconstitution in STAT1 gain-of-function.Journal of human immunity · 2026Article
- Dysbiosis-induced expansion of AXL-positive inflammatory type 3 dendritic cells triggers preclinical autoimmunity.Nature immunology · 2026Article
- Immune Dysregulation in Down Syndrome: Implications for Infectious Susceptibility and Vaccine Response.Journal of clinical immunology · 2026Review
- Fungal Infections in Disorders of Inborn Errors of Immunity.Clinical reviews in allergy & immunology · 2026Review
- Fludarabine disrupts the STAT1/AhR interaction to attenuate type 1 diabetes by inducing tolerogenic dendritic cells along with targeting effector T cells.Molecular medicine (Cambridge, Mass.) · 2026Article
- Repetitive transcranial magnetic stimulation modulates neuroinflammation and cell apoptosis via the interaction between Ifit3 and Stat1 for the treatment of neuropathic pain.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- A systems pharmacology-basedFrontiers in veterinary science · 2026Article
- Multi-omics highlights the impacts of cryptorchidism history on immune microenvironment variation in TGCT.Discover oncology · 2025Article
- Precision T cell correction platform for inborn errors of immunity.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- A Child with Chronic Mucocutaneous Candidiasis Harbors a Novel Gain-of-Function Mutation in STAT1.Journal of clinical immunology · 2025Article
- An activatingScience immunology · 2025Article
- Genetic, Transcriptomic, and Epigenomic Insights into Sjögren's Disease: An Integrative Network Investigation and Immune Diseases Comparison.International journal of molecular sciences · 2025Article
- Unphosphorylated STAT1 binds to the BST2 transcription promoter, promoting increased AKBA anchoring on HPMECs to alleviate ARDS.Scientific reports · 2025Article
- Identification of ferroptosis-related gene signatures as a novel prognostic model for clear cell renal cell carcinoma.Discover oncology · 2025Article
- A Norwegian cohort with STAT1-related disease - further expanding the clinical phenotype.Frontiers in immunology · 2025Article
- Clinical Characteristics Analysis of 30 Cases of Interferon-γ Autoantibody-Positive Patients with Concurrent Mycobacterial Infection: A 6-Year Retrospective Study.Infection and drug resistance · 2025Article
- PGRN Inhibits Early B-cell Activation and IgE Production Through the IFITM3-STAT1 Signaling Pathway in Asthma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Non-tuberculous mycobacterial infections in hematology-oncology: we need to look harder.Haematologica · 2024Article
- Immunophenotyping and Therapeutic Insights from Chronic Mucocutaneous Candidiasis Cases with STAT1 Gain-of-Function Mutations.Journal of clinical immunology · 2024Article
- Qualitative Immunoglobulin Deficiency Causes Bacterial Infections in Patients with STAT1 Gain-of-Function Mutations.Journal of clinical immunology · 2024Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Andrea D LargentSeattle Children's Research Institute, Seattle, WA 98101, USA.ORCID 0000-0003-2518-0469
Katharina LambertBenaroya Research Institute, Seattle, WA 98101, USA.ORCID 0000-0002-1998-0024
Kristy ChiangSeattle Children's Research Institute, Seattle, WA 98101, USA.ORCID 0000-0001-7322-0811
Natali ShumlakSeattle Children's Research Institute, Seattle, WA 98101, USA.ORCID 0000-0002-2692-2308
Denny LiggittDepartment of Comparative Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.
Mohammed OukkaDepartment of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA.
Troy R TorgersonAllen Institute for Immunology, Seattle, WA 98109, USA.ORCID 0000-0003-3489-5036
Jane H BucknerBenaroya Research Institute, Seattle, WA 98101, USA.ORCID 0000-0002-9005-1885
Eric J AllenspachSeattle Children's Research Institute, Seattle, WA 98101, USA.ORCID 0000-0001-7346-5835
David J RawlingsSeattle Children's Research Institute, Seattle, WA 98101, USA.ORCID 0000-0003-4370-4772
Shaun W JacksonSeattle Children's Research Institute, Seattle, WA 98101, USA.ORCID 0000-0002-7024-5252
University of Washington · USBenaroya Research InstituteAllen Institute for Immunology · US
Funding
RESEARCH TRAINING IN RHEUMATOLOGYT32AR007108 · NIAMS · UNIVERSITY OF WASHINGTON · PI Shaun Jackson, Tomas M Mustelin · 1986 to 2026
$6.6MMechanisms of IL-6 mediated T cell pathogenesis in autoimmunityR01AI132774 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI BUCKNER, JANE HOYT · 2017 to 2020
$6.4MAn integrated strategy to define the functional and synergistic impact of T1D causal variantsDP3DK111802 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI RAWLINGS, DAVID J · 2016 to 2016
$4.4MMechanistic insights into systemic lupus erythematosus (SLE) pathogenesis from inborn errors of immunityR01AR073938 · NIAMS · SEATTLE CHILDREN'S HOSPITAL · PI Shaun William Jackson · 2019 to 2026
$4.0MImpact of Loss-of-function NADPH Oxidase Variants on B-Cell Activation in SLER01AR075813 · NIAMS · SEATTLE CHILDREN'S HOSPITAL · PI JACKSON, SHAUN WILLIAM · 2021 to 2025
$2.8MB cell-intrinsic roles for STAT1 gain-of-function mutations in humoral autoimmunityR03AI139716 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI JACKSON, SHAUN WILLIAM · 2018 to 2019
$188kNIAID NIH HHS R01 AI132774NIAID NIH HHS R03 AI139716NIAMS NIH HHS R01 AR073938NIAMS NIH HHS R01 AR075813NIAMS NIH HHS T32 AR007108NIDDK NIH HHS DP3 DK111802
Abstract
Heterozygous signal transducer and activator of transcription 1 (
Indexed as
AutoimmunityGain of Function MutationAnimalsChildHumansInflammationInterferon-gammaMiceSTAT1 Transcription FactorSyndromeInterferon-gammaSTAT1 protein, humanSTAT1 Transcription Factor
Identifiers
What Socratic holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.