Evidence map›Paper›PMID 37408271›Full record

ArticleCells2023

Genetic and Protein Network Underlying the Convergence of Rett-Syndrome-like (RTT-L) Phenotype in Neurodevelopmental Disorders.

Eric Frankel, Avijit Podder, Megan Sharifi, Roshan Pillai, Newell Belnap, Keri Ramsey, Julius Dodson, Pooja Venugopal, Molly Brzezinski, Lorida Llaci and 16 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Rett syndrome.Nature reviews. Disease primers · 2024
    Review
  2. Natural Course ofChildren (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 3 institutions in 1 country.

Eric FrankelNeurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Avijit PodderQuantitative Medicine Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.ORCID 0000-0002-8296-0034
Megan SharifiNeurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Roshan PillaiNeurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Newell BelnapNeurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Keri RamseyCenter for Rare Childhood Disorders (C4RCD), Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Julius DodsonNeurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Pooja VenugopalNeurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Molly BrzezinskiNeurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.ORCID 0000-0002-0417-3406
Lorida LlaciNeurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Brittany GeraldNeurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Gabrielle MillsNeurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Meredith Sanchez-CastilloCenter for Rare Childhood Disorders (C4RCD), Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Chris D BalakNeurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Szabolcs SzelingerNeurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Wayne M JepsenNeurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.ORCID 0000-0002-3020-6005
Ashley L SiniardNeurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Ryan RichholtNeurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Marcus NaymikNeurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Isabelle SchrauwenCenter for Statistical Genetics, Department of Neurology, Gertrude H. Sergievsky Center, Columbia University Medical Center, New York, NY 10032, USA.ORCID 0000-0001-7310-6082
David W CraigDepartment of Translational Genomics, University of Southern California, Los Angeles, CA 90033, USA.
Ignazio S PirasNeurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.ORCID 0000-0003-4024-3368
Matthew J HuentelmanNeurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.ORCID 0000-0001-7390-9918
Nicholas J SchorkQuantitative Medicine Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.ORCID 0000-0003-0920-5013
Vinodh NarayananNeurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Sampathkumar RangasamyNeurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.ORCID 0000-0003-2151-9162
Translational Genomics Research Institute · USColumbia University Irving Medical Center · USUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations of the X-linked gene encoding methyl-CpG-binding protein 2 (

Indexed as

Neurodevelopmental DisordersRett SyndromeHumansMethyl-CpG-Binding Protein 2MutationPhenotypeTranscription FactorsMethyl-CpG-Binding Protein 2Transcription Factorsatypical RTT syndromemethyl-CpG-binding protein 2neurodevelopmental disordersoverlapping phenotypeprotein–protein interaction networkRett syndromeRett-syndrome-like phenotype

Identifiers

PMID37408271
PMCPMC10217403
OpenAlexW4377242239

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.