Evidence mapPaperPMID 37408455Full record

ArticleThe British journal of psychiatry : the journal of mental science2023

Childhood attention-deficit hyperactivity disorder problems and mid-life cardiovascular risk: prospective population cohort study.

Ajay K Thapar, Lucy Riglin, Rachel Blakey, Stephan Collishaw, George Davey Smith, Evie Stergiakouli, Kate Tilling, Anita Thapar

Open access · hybridAbstract read
In one paragraph

Article in The British journal of psychiatry : the journal of mental science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ajay K ThaparDivision of Psychological Medicine and Clinical Neurosciences, Centre for Neuropsychiatric Genetics and Genomics, Wolfson Centre for Young People's Mental Health, Cardiff University School of Medicine, Cardiff, UK.ORCID 0000-0002-4589-8833
Lucy RiglinDivision of Psychological Medicine and Clinical Neurosciences, Centre for Neuropsychiatric Genetics and Genomics, Wolfson Centre for Young People's Mental Health, Cardiff University School of Medicine, Cardiff, UK.ORCID 0000-0002-5124-5230
Rachel BlakeyPopulation Health Sciences and MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Stephan CollishawDivision of Psychological Medicine and Clinical Neurosciences, Centre for Neuropsychiatric Genetics and Genomics, Wolfson Centre for Young People's Mental Health, Cardiff University School of Medicine, Cardiff, UK.ORCID 0000-0002-4296-820X
George Davey SmithPopulation Health Sciences and MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Evie StergiakouliPopulation Health Sciences and MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Kate TillingPopulation Health Sciences and MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Anita ThaparDivision of Psychological Medicine and Clinical Neurosciences, Centre for Neuropsychiatric Genetics and Genomics, Wolfson Centre for Young People's Mental Health, Cardiff University School of Medicine, Cardiff, UK.
University of Bristol · GBCardiff University · GB

Funding

Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_00011/3Medical Research Council MC_UU_00032/1Medical Research Council MR/L010305/1Wellcome Trust 204895Wellcome Trust 204895/Z/16/Z
6 · The paper itself

Abstract

backgroundIt is well-known that childhood attention-deficit hyperactivity disorder (ADHD) is associated with later adverse mental health and social outcomes. Patient-based studies suggest that ADHD may be associated with later cardiovascular disease (CVD) but the focus of preventive interventions is unclear. It is unknown whether ADHD leads to established cardiovascular risk factors because so few cohort studies measure ADHD and also follow up to an age where CVD risk is evident.

aimsTo examine associations between childhood ADHD problems and directly measured CVD risk factors at ages 44/45 years in a UK population-based cohort study (National Child Development Study) of individuals born in 1958.

methodChildhood ADHD problems were defined by elevated ratings on both the parent Rutter A scale and a teacher-rated questionnaire at age 7 years. Outcomes were known cardiovascular risk factors (blood pressure, lipid measurements, body mass index and smoking) at the age 44/45 biomedical assessment.

resultsOf the 8016 individuals assessed both during childhood and at the biomedical assessment 3.0% were categorised as having childhood ADHD problems. ADHD problems were associated with higher body mass index (

conclusionsChildhood ADHD problems predicted multiple cardiovascular risk factors by mid-life. These findings, when taken together with previously observed associations with cardiovascular disease in registries, suggest that individuals with ADHD could benefit from cardiovascular risk monitoring, given these risk factors are modifiable with timely intervention.

Indexed as

Attention Deficit Disorder with HyperactivityCardiovascular DiseasesAdultAgedChildCohort StudiesHeart Disease Risk FactorsHumansProspective StudiesRisk FactorsADHDChildhoodcohort studyepidemiologymid-life cardiovascular risk

Identifiers

PMID37408455
PMCPMC7615511
OpenAlexW4383301822

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.