Evidence map›Paper›PMID 37410014›Full record

ReviewExpert opinion on drug metabolism & toxicology

Asparaginase toxicity in Hispanic adult and pediatric patients with acute lymphoblastic leukemia: current understanding.

Amani Alqahtani, Diala Alhousari, Amir Ali, George Yaghmour, Etan Orgel, Emily Curran, Wendy Stock, Deepa Bhojwani, Houda Alachkar

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Expert opinion on drug metabolism & toxicology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amani AlqahtaniSchool of Pharmacy, University of Southern California, Los Angeles, CA, USA.
Diala AlhousariSchool of Pharmacy, University of Southern California, Los Angeles, CA, USA.
Amir AliUSC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA.
George YaghmourUSC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA.
Etan OrgelUSC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA.
Emily CurranThe Department of Medicine, Section of Hematology & Oncology at the University of Cincinnati College of Medicine.
Wendy StockSection of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA.
Deepa BhojwaniUSC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA.
Houda AlachkarSchool of Pharmacy, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0001-5567-5521

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VERONICA WENDY SETIAWAN · 1985 to 2026
$181.4M
Leveraging the TCR Repertoire to identify target neoantigens in FLT3-ITD positive Acute Myeloid LeukemiaR01CA248381 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ALACHKAR, HOUDA · 2021 to 2025
$1.8M
NCI NIH HHS P30 CA014089NCI NIH HHS R01 CA248381
6 · The paper itself

Abstract

introductionAsparaginase is essential to chemotherapy regimens for acute lymphoblastic leukemia (ALL). Survival of patients with ALL has improved since incorporating asparaginase into chemotherapy backbones. Hispanic patients have a higher incidence of ALL than other ethnicities and suffer inferior outcomes. The inferior outcome of Hispanics is due to several factors, including the increased incidence of high-risk genetic subtypes and susceptibility to treatment-related toxicity. AREAS COVERED: We summarize the current knowledge of asparaginase-related toxicity by comparing their incidence between Hispanic and non-Hispanic patients. These toxicities include hypersensitivity, hepatotoxicity, pancreatitis, thrombosis, and hypertriglyceridemia. The PubMed database and Google Scholar were used to search for this review from October 2022 to June 2023. EXPERT OPINION: Except for hepatotoxicity and hypertriglyceridemia secondary to asparaginase-based treatments, which may develop more frequently among Hispanic patients with ALL, other toxicities were comparable between Hispanic and non-Hispanic patients. Nevertheless, studies with larger cohorts and more accurate capturing of Hispanic ethnicity should be conducted to fill the gaps in the current knowledge.

Indexed as

Antineoplastic AgentsChemical and Drug Induced Liver InjuryHypertriglyceridemiaPrecursor Cell Lymphoblastic Leukemia-LymphomaAdultAsparaginaseChildHumansAntineoplastic AgentsAsparaginaseAcute lymphoblastic leukemia (ALL)AsparaginaseDrug toxicityHepatotoxicityHispanicsPharmacogenetics

Identifiers

PMID37410014
PMCPMC11516125

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.