Mitochondrial calcium uniporter deficiency in dentate granule cells remodels neuronal metabolism and impairs reversal learning.
Hadyn M Rose, Beatriz Ferrán, Rojina Ranjit, Anthony M Masingale, Daniel B Owen, Stacy Hussong, Michael T Kinter, Veronica Galvan, Sreemathi Logan, Carlos Manlio Díaz-García
Article in Journal of neurochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors at 3 institutions in 1 country.
Hadyn M RoseDepartment of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Beatriz FerránDepartment of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Rojina RanjitDepartment of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Anthony M MasingaleDepartment of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Daniel B OwenDepartment of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Stacy HussongDepartment of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Michael T KinterAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.
Veronica GalvanDepartment of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Sreemathi LoganDepartment of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.ORCID 0000-0001-9160-0383
Carlos Manlio Díaz-GarcíaDepartment of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.ORCID 0000-0002-4352-2496
University of Oklahoma Health Sciences Center · USOklahoma City VA Health Care System · USOklahoma Medical Research Foundation · US
Funding
Visualizing insulin actions on neuronal metabolism and function using fluorescent biosensorsP20GM125528 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Carlos Manlio Diaz Garcia · 2019 to 2026
$17.8M
Targeted DNA Methylation and Mitochondrial Heteroplasmy CoreP30AG050911 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Matthew John Hart · 2015 to 2026
$13.9M
GEROSCIENCE TRAINING PROGRAM IN OKLAHOMAT32AG052363 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Benjamin Francis Miller, William Edmund Sonntag · 2017 to 2026
$3.6M
Tau-induced astrocyte senescence in Alzheimer's diseaseRF1AG068283 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI GALVAN, VERONICA, VAN REMMEN, HOLLY · 2020 to 2020
$1.6M
IGF-1 Regulation of Astrocyte Mitochondrial Metabolism and Redox Homeostasis in Brain AgingR00AG056662 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LOGAN, SREEMATHI · 2020 to 2022
$996k
The Role of Neuronal mTORC1 in Alzheimer's DiseaseIK2BX003798 · VA · SOUTH TEXAS VETERANS HEALTH CARE SYSTEM · PI HUSSONG, STACY A. · 2018 to 2022
–
Mechanism through which chronically elevated mTOR activity impairs aged muscle recovery after disuse atrophyI01BX005592 · VA · OKLAHOMA CITY VA MEDICAL CENTER · PI MILLER, BENJAMIN FRANCIS · 2022 to 2025
–
Pathogenic Tau Promotes Brain Vascular Dysfunction in Alzheimer's DiseaseI01BX002211 · VA · SOUTH TEXAS VETERANS HEALTH CARE SYSTEM · PI GALVAN, VERONICA · 2015 to 2025
–
American Federation for Aging ResearchBLRD VA I01 BX002211BLRD VA I01 BX005592BLRD VA IK2 BX003798BLRD VA IK6 BX006026NIA NIH HHS P30 AG050911NIA NIH HHS P30AG050911NIA NIH HHS R00 AG056662NIA NIH HHS R00AG056662NIA NIH HHS RF1 AG068283NIA NIH HHS T32 AG052363NIGMS NIH HHS 1P20GM125528NIGMS NIH HHS 5P20GM125528-04NIGMS NIH HHS P20 GM125528Presbyterian Health Foundation Bridge Grant
6 · The paper itself
Abstract
The mitochondrial calcium uniporter (MCU) is the main route of calcium (Ca
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Mitochondrial calcium uniporter deficiency in dentate granule cells remodels neuronal metabolism and impairs reversal learning. · full record | Socratic