Evidence map›Paper›PMID 37415404›Full record

ArticleIslets2023

EP3 signaling is decoupled from the regulation of glucose-stimulated insulin secretion in β-cells compensating for obesity and insulin resistance.

Michael D Schaid, Jeffrey M Harrington, Grant M Kelly, Sophia M Sdao, Matthew J Merrins, Michelle E Kimple

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Islets, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. GαJournal of the Endocrine Society · 2024
    Article
  4. The prostaglandin EAmerican journal of physiology. Endocrinology and metabolism · 2024
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Michael D SchaidDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI, USA.
Jeffrey M HarringtonDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI, USA.
Grant M KellyDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI, USA.
Sophia M SdaoDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI, USA.
Matthew J MerrinsDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI, USA.
Michelle E KimpleDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI, USA.
University of Wisconsin–Madison · USWilliam S. Middleton Memorial Veterans Hospital · US

Funding

Mitochondrial ADP privation: A unifying model for glucose-induced insulin secretion.R01DK127637 · YALE UNIVERSITY · 2025 to 2025
$685k
Metabolic Functions of Pyruvate Kinase M2 in Pancreatic Beta-cellsR01DK113103 · UNIVERSITY OF WISCONSIN-MADISON · 2025 to 2025
$485k
Metabolic regulation of islet hormone secretion in diabetesI01BX005113 · VA · WM S. MIDDLETON MEMORIAL VETERANS HOSP · 2022 to 2025
–
G protein mediated mechanisms of beta-cell compensation and failure in type 2 diabetesI01BX005804 · VA · WM S. MIDDLETON MEMORIAL VETERANS HOSP · 2023 to 2025
–
BLRD VA I01 BX003700BLRD VA I01 BX005113BLRD VA I01 BX005804NIDDK NIH HHS R01 DK102598NIDDK NIH HHS R01 DK113103NIDDK NIH HHS R01 DK127637
6 · The paper itself

Abstract

Of the β-cell signaling pathways altered by obesity and insulin resistance, some are adaptive while others contribute to β-cell failure. Two critical second messengers are Ca

Indexed as

Diabetes Mellitus, Type 2Insulin ResistanceIslets of LangerhansAnimalsGlucoseInsulinInsulin SecretionLeptinMiceMice, Inbred C57BLObesitySignal TransductionGlucoseInsulinLeptincAMPDiabetesEP3 receptorGɑzhyperglycemiainsulin secretionprostaglandinsRap1gapβ-cell

Identifiers

PMID37415404
PMCPMC10332234
OpenAlexW4383482260

What Socratic holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.