Evidence map›Paper›PMID 37415965›Full record

ArticleFrontiers in veterinary science2023

Evaluation of safety and efficacy of the bone marrow mesenchymal stem cell and gelatin-nano-hydroxyapatite combination in canine femoral defect repair.

Zihang Ma, Xiaoying Guo, Jun Zhang, Qifeng Jiang, Wuying Liang, Wenxin Meng, Shuaijiang Chen, Yufan Zhu, Cundong Ye, Kun Jia

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in veterinary science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Zihang MaCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Xiaoying GuoCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Jun ZhangCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Qifeng JiangCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Wuying LiangCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Wenxin MengCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Shuaijiang ChenCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Yufan ZhuCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Cundong YeCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Kun JiaCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
South China Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Femoral shaft fracture is a common bone trauma in dogs. The limitation of mesenchymal stem cells in bone defect applications is that the cell suspension cannot be fixed to the bone defect site. In the study, our objective was to substantiate the combined application of canine bone marrow mesenchymal stem cells (cBMSCs) and gelatin-nano-hydroxyapatite (Gel-nHAP) and evaluate its therapeutic effect on bone defect diseases in dogs. Experiments were performed to evaluate the following: (1) the porosity of Gel-nHAP; (2) the adhesion of cBMSCs to Gel-nHAP; and (3) the effect of Gel-nHAP on cBMSC proliferation. The efficacy and safety of the combination of cBMSC and Gel-nHAP in the repair of femoral shaft defects were evaluated in animal experiments. The results showed that Gel-nHAP supported the attachment of cBMSCs and exhibited good biocompatibility. In the animal bone defect repair experiment, significant cortical bone growth was observed in the Gel-nHAP group at week 8 (

Indexed as

bone defectbone tissue engineeringcanine bone marrow mesenchymal stem cellsco-culturegelatinhydroxyapatite

Identifiers

PMID37415965
PMCPMC10320857
OpenAlexW4381511363

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.